“…Since the introduction of Staudinger’s macromolecular hypothesis a century ago, the chain paradigm of macromolecules has been well developed, and materials made of those long-chain molecules have become ubiquitous in the modern world. Recently, a trend is clear that the classical paradigm is shifting to expand the scope of Staudinger’s definition of polymers. , As an emerging class of macromolecules, giant molecule chains refer to the size-amplified version of classical linear polymers, yet with more accurate chemical structures (e.g., size, shape, sequence, and topology) and discrete molecular weights. − They are precisely and modularly synthesized from a library of giant monomers in an either main-chain or side-chain manner. , The giant monomers are commonly shape-persistent organic/inorganic nanoentities that possess particular symmetry, uniform sizes, and precise chemical compositions. Their species covers a broad range of elements, including molecular clusters, − polyoxometalates, , fullerenes, , polyhedral oligomeric sesquioxanes (POSS), − etc.…”