Precise control of the size and gap between gold nanocubes by surface-based synthesis for high SERS performance

Omar, Rana; Naciri, A. En; Fahes, Abeer; Jradi, Safi; Issa, Ali; Кузнецов, Д. К.; Shur, V. Ya.; Zelenovskiy, P.; Battie, Yann; Akil, Suzanna

doi:10.1039/c9sm02405k

Cited by 11 publications

(14 citation statements)

References 47 publications

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“…On this basis, the SEF for GNH reached ~10 12 against 2 × 10 9 for GNC and 10 9 for GNP. These values match the highest SEF value (10 14 ) found for BPE in the literature and highlights the ultrasensitivity of the produced substrates [15,16,26]. We can explain this sensitivity trend as a function of the shape by the electric field concentrated at the corners of GNP.…”

Section: Sers Enhancement As a Function Of Gnp Shapesupporting

confidence: 86%

“…A remarkably small intensity variation highlights a reproducibility of ~95%, which could be the lowest among the previously reported substrates fabricated by various techniques. [13][14][15][16][17][18] These findings are promising, especially This latter matches the plasmonic band (545 nm) of GNC and results in higher SERS intensity. Basically, the excitation energy plays a crucial role in SERS enhancement and must be the closer to the surface plasmon resonance peak [26].…”

Section: Sers Enhancement As a Function Of Gnp Shapementioning

confidence: 67%

“…With respect to the number of nanoparticles, we previously demonstrated that the number is strongly dependent on gold precursor concentration. [ 16 ] However, shape control is still not established by VIPS. As assessed above, we recently showed the possibility to fabricate non-spherical GNPs [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…More precisely, the minima and maxima have the sa and width, which indicates that GNPs size can be tuned by the PMMA h respect to the number of nanoparticles, we previously demonstrated that strongly dependent on gold precursor concentration. [16] However, shape not established by VIPS. As assessed above, we recently showed the poss cate non-spherical GNPs [26].…”

Section: Shape Control Through Altering the Synthesis Parametersmentioning

confidence: 98%

“…However, different physical, chemical, and biological methods have synthesized MNPs (Au, Pt, Cu, Al, etc.) of different shapes [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Advanced Large-Scale Nanofabrication Route for Ultrasensitive SERS Platforms Based on Precisely Shaped Gold Nanostructures

Akil¹,

Omar²,

Кузнецов

et al. 2021

Nanomaterials

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One of the key issues for SERS-based trace applications is engineering structurally uniform substrates with ultrasensitivity, stability, and good reproducibility. A label-free, cost-effective, and reproducible fabrication strategy of ultrasensitive SERS sensors was reported in this work. Herein, we present recent progress in self-assembly-based synthesis to elaborate precisely shaped and abundant gold nanoparticles in a large area. We demonstrated that shape control is driven by the selective adsorption of a cation (Na+, K+, and H+) on a single facet of gold nanocrystal seeds during the growth process. We studied SERS features as a function of morphology. Importantly, we found a correlation between the shape and experimental SERS enhancement factors. We observed a detection threshold of 10−20 M of bipyridine ethylene (BPE), which matches the lowest value determined in literature for BPE until now. Such novel sensing finding could be very promising for diseases and pathogen detection and opens up an avenue toward predicting which other morphologies could offer improved sensitivity.

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Section: Sers Enhancement As a Function Of Gnp Shapesupporting

confidence: 86%

Section: Sers Enhancement As a Function Of Gnp Shapementioning

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Section: Shape Control Through Altering the Synthesis Parametersmentioning

confidence: 98%

“…However, different physical, chemical, and biological methods have synthesized MNPs (Au, Pt, Cu, Al, etc.) of different shapes [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Advanced Large-Scale Nanofabrication Route for Ultrasensitive SERS Platforms Based on Precisely Shaped Gold Nanostructures

Akil¹,

Omar²,

Кузнецов

et al. 2021

Nanomaterials

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Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Mahmud²,

et al. 2021

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Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due to their unique characteristics such as tunable surface properties as well as surface plasmon resonance (SPR), GNPs have garnered attention in various applications exclusively in therapy and diagnostics. Their ease of synthesis and compatibility with various functionalizing ligands has made them efficient and a robust biomedical platform. Due to their flexibility in synthesis and functionalization, GNPs have been profoundly used in cancer treatment as well as, antiviral, and antibacterial agents. In addition, owing to possessing unique optical properties, GNPs have been utilized as molecular imaging and contrast agent. This article discusses and highlights special characteristics of GNPs that have been exploited in biomedical applications in recent years to improve biomedical research in various biomedical field such as nuclear medicine, molecular imaging and contrast agent, vaccine development, medical implant, diagnostics, biosensing, and lab‐on‐chip applications. Moreover, their size dependent biocompatibility, biodistribution, and excreation was discussed in details for various in vivo applications. At the forefront of modern theraputic technology, GNPs based cancer treatment and antiviral agents have great potential which is also highlighted briefly in this article. In addition, current state of ongoing clinical trials and challenges associated with regulatory approval are explored. Lastly, the article sheds light on recent findings on the toxicity of GNPs and discusses the current challenges and prospects to future direct GNPs based biomedical research.

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Gold nanorods coated by molecularly imprinted polymer for sensitive and specific SERS detection of dyes

2023

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Precise control of the size and gap between gold nanocubes by surface-based synthesis for high SERS performance

Abstract: Gold nanocubes with tunable size and interparticle gap were produced by altering the spin-coating speed of PMMA/gold precursor dispersion on silicon substrate. Then, their optical properties were provided by spectroscopic ellipsometry measurements.

Cited by 11 publications

References 47 publications

Advanced Large-Scale Nanofabrication Route for Ultrasensitive SERS Platforms Based on Precisely Shaped Gold Nanostructures

Advanced Large-Scale Nanofabrication Route for Ultrasensitive SERS Platforms Based on Precisely Shaped Gold Nanostructures

Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Gold nanorods coated by molecularly imprinted polymer for sensitive and specific SERS detection of dyes

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