Precise CRISPR/Cpf1 genome editing system in the Deinococcus radiodurans with superior DNA repair mechanisms

Chen, Zijing; Hu, Jing; Dai, Jingli; Zhou, Congli; Hua, Yuejin; Hua, Xiaoting; Zhao, Ye

doi:10.1016/j.micres.2024.127713

Microbiological Research

2024

DOI: 10.1016/j.micres.2024.127713

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Precise CRISPR/Cpf1 genome editing system in the Deinococcus radiodurans with superior DNA repair mechanisms

Zijing Chen,

Jing Hu,

Jingli Dai

et al.

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From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Saliev,

Singh

2024

Cells

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Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, and cellular senescence—these therapies aim to restore youthful functionality to cells and tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased a range of strategies, including epigenetic reprogramming, senolytic interventions, mitochondrial restoration, stem cell-based approaches, and gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential in preclinical models and is now being cautiously explored in early-stage clinical trials. However, translating these therapies from the laboratory to clinical practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, and high costs impede widespread adoption. This review examines the current landscape of cellular rejuvenation, highlighting key advancements, potential risks, and the strategies needed to overcome these hurdles.

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From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Saliev,

Singh

2024

Cells

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Precise CRISPR/Cpf1 genome editing system in the Deinococcus radiodurans with superior DNA repair mechanisms

Cited by 1 publication

References 54 publications

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

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