Precise manipulation of cell behaviors on surfaces for construction of tissue/organs

Zheng, Wenfu; Jiang, Xingyu

doi:10.1016/j.colsurfb.2014.08.026

Cited by 15 publications

(10 citation statements)

References 160 publications

(205 reference statements)

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“…Tissue engineering [85][86][87][88][89][90] frequently involves cell assemblies that can actually be simpler and at least during the processes of their making be also less subjected to external influences than cells in natural tissues. Therefore, they might actually be easier to model within our approach.…”

Section: Heterogeneous and External Effects And Possible Model Extenmentioning

confidence: 99%

Lattice percolation approach to numerical modelling of tissue aging

Privman

Gorshkov

Libert

2015

International Journal of Parallel, Emergent and Distributed Sys

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We describe a percolation-type approach to modeling of the processes of aging and certain other properties of tissues analyzed as systems consisting of interacting cells. Tissues are considered as structures made of regular healthy, senescent, dead (apoptotic) cells, and studied dynamically, with the ongoing processes including regular cell division to fill vacant sites left by dead cells, healthy cells becoming senescent or dying, and other processes. Statistical-mechanics description can provide patterns of time dependence and snapshots of morphological systemproperties. An illustrative application of the developed theoretical modeling approach is reported, confirming recent experimental findings that inhibition of senescence can lead to extended lifespan.

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Section: Heterogeneous and External Effects And Possible Model Extenmentioning

confidence: 99%

Lattice percolation approach to numerical modelling of tissue aging

Privman

Gorshkov

Libert

2015

International Journal of Parallel, Emergent and Distributed Sys

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“…Within the tube, the two types of cells directly interact and communicate with each other, mimicking the in vivo conditions of blood vessel . These tubular structures may be of great use in tissue engineering …”

Section: Application Of Microfluidics‐based Analysismentioning

confidence: 99%

Microfluidics for Biomedical Analysis

et al. 2019

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Many new techniques and materials have been applied to microfluidic systems in the past decade, and integrated microfluidic chips have become powerful platforms for realizing highly sensitive, high throughput, and low‐cost analysis. This article reviews the latest advancements of microfluidic platforms for biological and biomedical analysis in the fields of fundamental biology research, clinical application, food safety, and environmental monitoring, with a focus on nucleic acid‐based molecular diagnosis and protein‐based immunodiagnosis. The combination of microfluidics with advanced techniques (e.g., nanotechnology, 3D printing, deep learning) would offer innovative new tools for bioanalyses. The current challenges and the future developments of microfluidic technologies for clinical applications are also discussed. It is anticipated that this review will be beneficial to promoting microfluidics toward a broad range of applications in the future.

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“…As a biomimetic microphysiological system for culturing living cells in vitro, microfluidics‐based organ‐on‐a‐chip could provide continuously perfused chambers to simulate extracellular microenvironment and physiological functionality of human tissues/organs . Unlike traditional 2D or 3D in vitro cell culture systems, organs‐on‐chips integrated with microfluidics technologies offer compelling advantages in real‐time imaging and high‐resolution analysis of genetic, biochemical, and metabolic activities .…”

Section: Cells‐on‐chipsmentioning

confidence: 99%

Microfluidics‐Based Biomaterials and Biodevices

et al. 2018

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805033.The rapid development of microfluidics technology has promoted new innovations in materials science, particularly by interacting with biological systems, based on precise manipulation of fluids and cells within microscale confinements. This article reviews the latest advances in microfluidics-based biomaterials and biodevices, highlighting some burgeoning areas such as functional biomaterials, cell manipulations, and flexible biodevices. These areas are interconnected not only in their basic principles, in that they all employ microfluidics to control the makeup and morphology of materials, but also unify at the ultimate goals in human healthcare. The challenges and future development trends in biological application are also presented. Microfluidics

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Precise manipulation of cell behaviors on surfaces for construction of tissue/organs

Cited by 15 publications

References 160 publications

Lattice percolation approach to numerical modelling of tissue aging

Lattice percolation approach to numerical modelling of tissue aging

Microfluidics for Biomedical Analysis

Microfluidics‐Based Biomaterials and Biodevices

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