2019
DOI: 10.1002/elps.201900103
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Precise measurement and control of the pressure‐driven flows for microfluidic systems

Abstract: Precise measurement and control of the pressure-driven flows for microfluidic systemsThe pressure-driven device is designed and the flow rates of the microfluidic systems can be supplied by the pressure-driven flows, which can significantly reduce the flowrate fluctuations coming from the pump source. For pressure-driven flows, the flow rates of the fluids can be predicted by measuring the pressure drop along a polytetrafluoroethylene (PTFE) tubing. Especially, by varying the geometrical parameters of the PTFE… Show more

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Cited by 5 publications
(8 citation statements)
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“…Almost all microfluidic studies used for characterizing LSCI and MESI systems have been performed using syringe pumps. This study corroborates previous work 26, 28, 30 that has shown syringe pumps do not produce stable flow outputs and demonstrates that single-exposure LSCI is sensitive enough to detect the resulting flow anomalies (Fig. 5).…”
Section: Discussionsupporting
confidence: 91%
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“…Almost all microfluidic studies used for characterizing LSCI and MESI systems have been performed using syringe pumps. This study corroborates previous work 26, 28, 30 that has shown syringe pumps do not produce stable flow outputs and demonstrates that single-exposure LSCI is sensitive enough to detect the resulting flow anomalies (Fig. 5).…”
Section: Discussionsupporting
confidence: 91%
“…Pressure-driven flow control systems overcome the limitations of syringe pumps by eliminating the use of a motor and lead screw to provide very stable flow. 26, 28, 30 These systems use pressure-regulated air to push liquid from a reservoir through the microfluidic device at a constant flow rate. 30 In order to control the applied pressure, an absolute flow sensor must be added inline with the microfluidic device.…”
Section: Introductionmentioning
confidence: 99%
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“…12−14 In this circumstance, positive pressurization is preferable for driving the on-chip immunoassay because of its precise control, minimal tubing retention, and low crosscontamination 15 while providing a stable force to protect cells from shear forces and avoid over-pressuring. 16,17 However, pressurization in microfluidic devices leads to difficulties in precise flow regulation and bubble removal. Longwell and Fordyce creatively allowed bubble escape through a bypass in their microIO system and obtained minimal cross-contamination.…”
Section: Introductionmentioning
confidence: 99%
“…External forces, including sound waves, laser irradiation, and magnetic fields, have been employed to facilitate mixing, but the accompanying instrumentation requirements increase the difficulty of integration . Pump-activated micromixers have also been used, but they rely on accurate coordination of pneumatic valves and complicated chip fabrication. In addition, extensive investigation of the heterogeneity of CTC population requires isolation of a single CTC distribution with low background interferences, minimal cell damage, and accurate manipulation. In this circumstance, positive pressurization is preferable for driving the on-chip immunoassay because of its precise control, minimal tubing retention, and low cross-contamination while providing a stable force to protect cells from shear forces and avoid over-pressuring. , However, pressurization in microfluidic devices leads to difficulties in precise flow regulation and bubble removal. Longwell and Fordyce creatively allowed bubble escape through a bypass in their microIO system and obtained minimal cross-contamination .…”
Section: Introductionmentioning
confidence: 99%