Precise Molecular Structures of Cysteine, Cystine, Hydrogen-Bonded Dicysteine, Cysteine Dipeptide, Glutathione and Acetyl Cysteine Based on Additivity of Atomic Radii

Heyrovská, Raji

doi:10.1038/npre.2011.6692.1

Cited by 6 publications

(8 citation statements)

References 10 publications

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“…These results suggest that the helical geometry, and not only chirality by itself, may also be needed for the emergence of unconventional superconductivity. However, we cannot rule out at this stage that the absence OP change is due to the shorter length of the cysteine molecules (~0.7nm [56]) compared to the alpha-helix polyaniline molecules (3 nm). Further studies are needed in order to resolve this issue.…”

Section: Bilayersmentioning

confidence: 93%

Unconventional order parameter induced by helical chiral molecules adsorbed on a metal proximity coupled to a superconductor

et al. 2018

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Following our previous results, which provide evidence for the emergence of a chiral p-wave tripletpairing component in superconducting Nb upon the adsorption of chiral molecules, we turned to investigate whether such an effect can take place in a proximal superconductor consisting of metal on superconductor bilayer. Note that in such proximity systems, correlated electron-hole (Andreev) pairs exist in the normal metal rather than genuine Cooper pairs. To that end, we used scanning tunneling spectroscopy (STS) on thin Au films grown in-situ on NbN (a conventional s-wave superconductor) before and after adsorbing helical chiral, alpha-helix polyalanine molecules. The tunneling spectra measured on the pristine Au surface showed conventional (s-wave like) proximity gaps. However, upon molecules adsorption the spectra significantly changed, all exhibiting a zero-bias conductance peak embedded inside a gap, indicating unconventional superconductivity. The peak reduced with magnetic field but did not split, consistent with equal-spin triplet-pairing p-wave symmetry. In contrast, adsorption of non-helical chiral cysteine molecules did not yield any apparent change in the order parameter, and the tunneling spectra exhibited only gaps free of in-gap structure.

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Section: Bilayersmentioning

confidence: 93%

Unconventional order parameter induced by helical chiral molecules adsorbed on a metal proximity coupled to a superconductor

et al. 2018

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“…However, the relative thicknesses should be much more accurate. Since these thicknesses are in the order of the molecular dimensions (6.6 Å × 7.1 Å), this indicates that the coverage is approximately one monolayer.…”

Section: Methodsmentioning

confidence: 99%

Investigations into Spin- and Unpolarized Secondary Electron-Induced Reactions in Self-Assembled Monolayers of Cysteine

2021

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Cysteine is the simplest thiolated, chiral amino acid and is often used as the anchor for studies of self-assembled monolayers (SAMs) of complex biomolecules such as peptides. Understanding the interaction of SAMs of cysteine with low-energy secondary electrons (SEs) produced by X-rays can further our understanding of radiation damage in biomolecules. In particular, if the electrons are polarized, chiral-selective chemistry could have bearing on the origin of homochirality in nature. In the present paper, we use synchrotron radiation-based X-ray photoelectron spectroscopy to determine the changes that occur in the bonding of self-assembled layers of cysteine on gold as a result of soft X-ray irradiation. To investigate the possibility of chiral selectivity resulting from the interaction of low-energy, spin-polarized SEs (SPSEs), measurements were conducted on cysteine adsorbed on a 3 nm-thick gold layer deposited on a CoPt thin-film multilayer with perpendicular magnetic anisotropy. Time-dependent measurements of the C 1s, N 1s, O 1s, S 2p, and Au 4f core levels are used to follow the changes in surface chemistry and determine reaction cross-sections as a function of SE exposure. Analysis of the data results in cross-sections in the range of 5–7 Mb and suggests possible reaction pathways. Changing the magnetization direction of the CoPt multilayer produces SPSEs with opposite polarity. Some evidence of spin-dependent reactions is indicated but is inconclusive. Possible reasons for the discrepancy are posited.

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“…The molecular structure of L‐cysteine with the respective bond lengths is shown in Figure 1. Based on the additivity of covalent atomic radii in bond lengths, the L‐cysteine molecule has approximate dimensions of 6.6 × 7.1 Å 6 . It has been reported that L‐cysteine anchors to the metal surface using either chemisorption (similar to thiolate–metal bonding) or physisorption (similar to the bonding to metal surfaces by the amino and carboxyl functional groups).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the additivity of covalent atomic radii in bond lengths, the L-cysteine molecule has approximate dimensions of 6.6 Â 7.1 Å. 6 It has been reported that Lcysteine anchors to the metal surface using either chemisorption (similar to thiolate-metal bonding) or physisorption (similar to the bonding to metal surfaces by the amino and carboxyl functional groups). Several experimental and theoretical research studies have been conducted previously to elucidate the absorption behaviors of L-cysteine on different metals, and according to them, the L-cysteine adsorption on metallic surfaces is very strong due to the multifunctional anchoring behavior.…”

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confidence: 99%

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Ultraviolet photoelectron spectroscopic study on the interface electronic structure of the L‐cysteine on Pd surface

Koswattage

Liyanage

Maduwantha

2022

Surface & Interface Analysis

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L-cysteine is one of the most versatile biomolecules with a unique metal-binding ability. L-cysteine has an outstanding role in the bioelectronics field as a linker between proteins of biomolecules and metal electrodes of the inorganic metals through multiple functional groups. The interface electronic structures between L-cysteine with metals deserve further investigation for applications in bioelectronics. However, the interface electronic structures of L-cysteine and metals have not been well understood. We have previously reported the existence of a new state between the highest occupied molecular orbital (HOMO) of L-cysteine and the Fermi level of the metals for L-cysteine/Au(111), L-cysteine/Ag(111), and L-cysteine/Cu(111) using photoemission spectroscopy and attributed the formation of the new state to an interaction of the d band with HOMO of L-cysteine. In this study, the electronic structure at the interfaces of L-cysteine on a Palladium (Pd) surface is investigated by ultraviolet photoemission spectroscopy (UPS) using synchrotron radiation including work function, secondary electron cutoff (SECO), and HOMO onset; the position of an interface state, charge injection barrier, and ionization energy are estimated. It is observed that thin-film spectra of L-cysteine on Pd surfaces in the valance top region are different from the L-cysteine thick films, and this can be attributed to an interaction between a sulfur-originated state of L-cysteine HOMO with Pd d orbitals. Also, a 0.6-eV SECO shift is estimated due to the charge transferring between L-cysteine and Pd. The results of SECO further confirm the weakening of the Pd-sulfur bond with increasing L-cysteine coverage on Pd.

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Precise Molecular Structures of Cysteine, Cystine, Hydrogen-Bonded Dicysteine, Cysteine Dipeptide, Glutathione and Acetyl Cysteine Based on Additivity of Atomic Radii

Cited by 6 publications

References 10 publications

Unconventional order parameter induced by helical chiral molecules adsorbed on a metal proximity coupled to a superconductor

Unconventional order parameter induced by helical chiral molecules adsorbed on a metal proximity coupled to a superconductor

Investigations into Spin- and Unpolarized Secondary Electron-Induced Reactions in Self-Assembled Monolayers of Cysteine

Ultraviolet photoelectron spectroscopic study on the interface electronic structure of the L‐cysteine on Pd surface

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