Precise nanomedicine for intelligent therapy of cancer

Chen, Huabing; Gu, Zhennan; An, Hong‐Wei; Chen, Chunying; Chen, Jie; Cui, Ran; Chen, Siqin; Chen, Weihai; Chen, Xuesi; Chen, Xiaoyuan; Chen, Zhuo; Ding, Baoquan; Dong, Qian; Fan, Qin; Fu, Ting; Hou, Da‐Yong; Ke, Hengte; Jiang, Xiqun; Liu, Gang; Li, Suping; Li, Tianyu; Liu, Zhuang; Nie, Guangjun; Ovais, Muhammad; Pang, Dai‐Wen; Qiu, Nasha; Shen, Youqing; Tian, Huayu; Wang, Chao; Wang, Hao; Wang, Ziqi; Xu, Huaping; Xu, Jiang; Yang, Xiangliang; Zhu, Shuang; Zheng, Xianchuang; Zhang, Xian‐Zheng; Zhao, Yufang; Tan, Weihong; Zhang, Xi; Zhao, Yuliang

doi:10.1007/s11426-018-9397-5

Cited by 375 publications

(261 citation statements)

References 673 publications

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“…Gene therapy is one of the most promising approaches for the treatment of serious human diseases, the choice of gene vectors, and therapeutic strategies are of primary concern. Supramolecular gene vectors are widely studied in the realm of gene therapy because of their special responsiveness . In this work, the key issue of our research is to artificially control the redox‐response process of supramolecular assemblies to achieve efficient gene delivery.…”

Section: Introductionmentioning

confidence: 99%

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Zhang

Wang

et al. 2019

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Microenvironment‐responsive supramolecular assemblies have attracted great interest in the biomedical field due to their potential applications in controlled drug release. In this study, oxidation‐responsive supramolecular polycationic assemblies named CPAs are prepared for nucleic acid delivery via the host–guest interaction of β‐cyclodextrin based polycations and a ferrocene‐functionalized zinc tetraaminophthalocyanine core. The reactive oxygen species (ROS) can accelerate the disassembly of CPA/pDNA complexes, which would facilitate the release of pDNA in the complexes and further benefit the subsequent transfection. Such improvement in transfection efficiency is proved in A549 cells with high H2O2 concentration. Interestingly, the transfection efficiencies mediated by CPAs are also different in the presence or absence of light in various cell lines such as HEK 293 and 4T1. The single oxygen (1O2), produced by photosensitizers in the core of CPAs under light, increases the ROS amount and accelerates the disassembly of CPAs/pDNA complexes. In vitro and in vivo studies further illustrate that suppressor tumor gene p53 delivered by CPAs exhibits great antitumor effects under illumination. This work provides a promising strategy for the design and fabrication of oxidation‐responsive nanoassemblies with light‐enhanced gene transfection performance.

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Section: Introductionmentioning

confidence: 99%

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Zhang

Wang

et al. 2019

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“…As a result, combined PTT–PDT has been widely investigated. PTT can increase oxygen in the tumor by improving blood flow, and increase the cellular uptake efficiency of photosensitizers, resulting in more effective PDT . Photosensitizers could be loaded on 2D nanomaterials to increase dispersibility, enhance accumulation in tumors and achieve on‐demand release.…”

Section: D Nanomaterials For Ptt‐based Synergistic Therapymentioning

confidence: 99%

Two‐Dimensional Nanomaterials for Photothermal Therapy

2020

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Two‐dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT‐based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT‐synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented.

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“…[31] Inorganic and metallic O 2 −• generators such as TiO 2 and ZnO generally activated by UV-light suffer from potential side-effect and lowpenetration. [36][37][38] It still remains a key challenge to develop novel NIR-trigged O 2 −• generators to circumvent the tumor hypoxia. [36][37][38] It still remains a key challenge to develop novel NIR-trigged O 2 −• generators to circumvent the tumor hypoxia.…”

Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC‐UiO) comprised of bacteriochlorin ligand and Hf 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 clusters to address this tricky issue are designed. The resulting DBBC‐UiO enables numerous superoxide anion radical (O 2 −• ) generation via a type I mechanism with a 750 nm NIR‐laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O 2 ) through superoxide dismutase (SOD)‐mediated catalytic reactions under severe hypoxic microenvironment (2% O 2 ), and the partial recycled O 2 enhances O 2 −• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC‐UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

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Precise nanomedicine for intelligent therapy of cancer

Cited by 375 publications

References 673 publications

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy

Two‐Dimensional Nanomaterials for Photothermal Therapy

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

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