We analyze and review the theory of the hydrogen-deuterium isotope shift for the 1S-2S transition, which is one of the most accurately measured isotope shifts in any atomic system, in view of a recently improved experiment. A tabulation of all physical effects that contribute to the isotope shift is given. These include the Dirac binding energy, quantum electrodynamic effects, including recoil corrections, and the nuclear-size effect, including the pertaining relativistic and radiative corrections. From a comparison of the theoretical result f th = 670 999 566.90(66)(60) kHz (exclusive of the nonrelativistic nuclear-finite-size correction) and the experimental result f expt = 670 994 334 605(15) Hz, we infer the deuteron-proton charge-radius difference r 2 d − r 2 p = 3.820 07(65) fm 2 and the deuteron structure radius r str = 1.975 07(78) fm.