Precise subcellular targeting approaches for organelle-related disorders

Shim, Gayong; Youn, Yu Seok

doi:10.1016/j.addr.2024.115411

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115411

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Precise subcellular targeting approaches for organelle-related disorders

Gayong Shim,

Yu Seok Youn

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Cited by 4 publications

References 193 publications

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Mimicomes: Mimicking Multienzyme System by Artificial Design

Cao,

Jiang,

Chen

et al. 2024

Adv Healthcare Materials

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Enzymes are widely distributed in organelles of cells, which are capable of carrying out specific catalytic reactions. In general, several enzymes collaborate to facilitate complex reactions and engage in vital biochemical processes within cells, which are also called cascade systems. The cascade systems are highly efficient, and their dysfunction is associated with a multitude of endogenous diseases. The advent of nanotechnology makes it possible to mimic these cascade systems in nature and realize partial functions of natural biological processes both in vitro and in vivo. To emphasize the significance of artificial cascade systems, mimicomes is first proposed, a new concept that refers to the artificial cascade catalytic systems. Typically, mimicomes are able to mimic specific natural biochemical catalytic processes or facilitate the overall catalytic efficiency of cascade systems. Subsequently, the evolution and development of different types of mimicomes in recent decades are elucidated exhaustedly, from the natural enzyme‐based mimicomes (immobilized enzyme and vesicle mimicomes) to the nanozyme‐based mimicomes and enzyme‐nanozyme hybrid mimicomes. In conclusion, the remaining challenges in the design of multifunctional mimicomes and their potential applications are summarized, offering insights into their future prospects.

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Mimicomes: Mimicking Multienzyme System by Artificial Design

Cao,

Jiang,

Chen

et al. 2024

Adv Healthcare Materials

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Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness

Youn,

Raemdonck

2025

Advanced Drug Delivery Reviews

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Cellular Takeover: How New World Alphaviruses Impact Host Organelle Function

VanderGiessen,

Jamiu,

Heath

et al. 2024

Virology

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Precise subcellular targeting approaches for organelle-related disorders

Cited by 4 publications

References 193 publications

Mimicomes: Mimicking Multienzyme System by Artificial Design

Mimicomes: Mimicking Multienzyme System by Artificial Design

Editorial: Subcellular organelle-targeting of nanomaterials for enhancing therapeutic effectiveness

Cellular Takeover: How New World Alphaviruses Impact Host Organelle Function

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