Precisely designed Fex (x = 1–2) cluster nanocatalysts for effective nanocatalytic tumor therapy

Meng, Yanfei; Zhang, Dongsheng; Song, Yingzi; Yang, Xinyi; Gao, Yongli; Ma, Jun; Hu, Zunfu; Zheng, Xiuwen

doi:10.1039/d2nr05869c

Cited by 2 publications

(5 citation statements)

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“…Upon loading of tamoxifen (antitumor drug), the catalytic efficiency of the nanocatalyst was significantly enhanced due to the down-regulation of intracellular pH. The up-regulated intracellular ROS could trigger LPO and subsequent ferroptosis in tumor cells . Nanozymes composed of atomically dispersed Fe and Pt has been proven to be effective catalyst to promote OH • synthesis via the Fenton reaction for tumor catalytic therapy .…”

Section: Mechanism and Regulationmentioning

confidence: 99%

“…The up-regulated intracellular ROS could trigger LPO and subsequent ferroptosis in tumor cells. 66 Nanozymes composed of atomically dispersed Fe and Pt has been proven to be effective catalyst to promote OH • synthesis via the Fenton reaction for tumor catalytic therapy. 67 The diatomic active sites of Fe and Pt exhibited synergistic peroxidase-like activity, effectively generated abundant OH • from intracellular H 2 O 2 to induce tumor cell death.…”

Section: Lipid Metabolismmentioning

confidence: 99%

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Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

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Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation of iron metabolism and the accumulation of lipid peroxides. This nonapoptotic mode of cell death is implicated in various physiological and pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. This article focuses on ferroptosis-based therapeutic strategies for precision cancer treatment, covering the molecular mechanisms of ferroptosis, four major types of ferroptosis inducers and their inhibitory effects on diverse carcinomas, the detection of ferroptosis by fluorescent probes, and their implementation in image-guided therapy. These state-of-the-art tactics have manifested enhanced selectivity and efficacy against malignant carcinomas. Given that the administration of ferroptosis in cancer therapy is still at a burgeoning stage, some major challenges and future perspectives are discussed for the clinical translation of ferroptosis into precision cancer treatment. ■ SIGNIFICANCE • The potential of ferroptosis as an innovative strategy for precision cancer therapy is highlighted. • Recent advances are discussed from three perspectives: molecular mechanism and regulation, anti-cancer ferroptosis inducers, and ferroptosis probes for image-guided therapy. • The strengths and weaknesses of ferroptosis modulators and probes are analyzed in terms of current progress and technical barriers. • Future perspectives are emphasized to advance ferroptosis-based therapies toward clinical use for cancer treatment.

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Section: Mechanism and Regulationmentioning

confidence: 99%

Section: Lipid Metabolismmentioning

confidence: 99%

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Shi,

Chen,

2024

J. Med. Chem.

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“…Chiral multiple metal nanomaterials represent a significant category within the realm of chiral plasmonic hybrid nanostructures. Examples of these materials include metal combination such as chiral Au/Ag, [52,61,99,104] Au/Cu, [14a] Au/Pd, [16b,105] Pt@Au, [47,49,72] Ag/Cu, [15,41] and Ag/Al. [15] These nanomaterials offer the advantage of manipulating local electromagnetic fields through the incorporation of additional metal constituents, resulting in the augmentation of existing or the emergence of new PCD signals.…”

Section: Chiral Multiple Metal Nanomaterialsmentioning

confidence: 99%

“…For the Au@Ag shell BPs, the maximum g-factor value can be achieved at ≈2 × 10 −3 . In addition, chiral molecules clearly guide the formation of multimetal NPs with helical shells, such as wrinkled Au@Pd, [16b] Au@Ag nanorods, [54,99] and Pt@Au nanorings (Figure 9b). [49] Of paramount importance is the role of chiral molecules in governing the origin of chirality and the subsequent optical properties in plasmonic systems.…”

Section: Role Of Chiral Molecules On Plasmonic Chirality Of Chiral Mu...mentioning

confidence: 99%

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Chiral Plasmonic Hybrid Nanostructures: A Gateway to Advanced Chiroptical Materials

Tan,

Fu,

Gao

et al. 2023

Advanced Materials

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Chirality introduces a new dimension of functionality to materials, unlocking new possibilities across various fields. When integrated with plasmonic hybrid nanostructures, this attribute synergizes with plasmonic and other functionalities, resulting in unprecedented chiroptical materials that push the boundaries of the system's capabilities. Recent advancements have illuminated the remarkable chiral light–matter interactions within chiral plasmonic hybrid nanomaterials, allowing for the harnessing of their tunable optical activity and hybrid components. These advancements have led to applications in areas such as chiral sensing, catalysis, and spin optics. Despite these promising developments, there remains a need for a comprehensive synthesis of the current state‐of‐the‐art knowledge, as well as a thorough understanding of the construction techniques and practical applications in this field. This review begins with an exploration of the origins of plasmonic chirality and an overview of the latest advancements in the synthesis of chiral plasmonic hybrid nanostructures. Furthermore, representative emerging categories of hybrid nanomaterials are classified and summarized, elucidating their versatile applications. Finally, the review engages with the fundamental challenges associated with chiral plasmonic hybrid nanostructures and offer insights into the future prospects of this advanced field.

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Precisely designed Fe_x (x = 1–2) cluster nanocatalysts for effective nanocatalytic tumor therapy

Abstract: Atomically dispersed metal clusters are considered as promising nanocatalysts due to their excellent physicochemical property. Here, we report a novel strategy for precisely design of Fex (x =1~2) cluster nanocatalysts...

Cited by 2 publications

References 40 publications

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer

Chiral Plasmonic Hybrid Nanostructures: A Gateway to Advanced Chiroptical Materials

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