Precision and sources of variability in the assessment of rheumatoid arthritis erosions by HRpQCT

Ibrahim-Nasser, Nada; Marotte, Hubert; Valéry, Antoine; Salliot, Carine; Toumi, Hechmi; Lespessailles, Éric

doi:10.1016/j.jbspin.2017.02.011

Cited by 11 publications

(9 citation statements)

References 34 publications

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“…A single study compared erosion volumes measured manually (estimated from width and depth and calculated assuming the erosion approximated a half-ellipsoid) and using MIAF and mESE. While erosion volumes were similar when measured with the semi-automated methods, manual measurements yield significantly lower absolute volume measures compared with semi-automated methods, particularly for irregularly shaped erosions, illustrating that the erosions should not be assumed to be shaped like a half-ellipsoid (47). To date, no other studies have compared other erosion measurement algorithms.…”

Section: Quantitative Evaluation Of Erosions From Hr-pqct Imagingmentioning

confidence: 89%

“…Erosion width and depth have been manually assessed using OsiriX medical imaging software (Pixmeo, Bernex, Switzerland) (48, 50, 62, 65). The erosion volume can then be estimated from a halfellipsoid formula (9,23,26,28,47,57) Figure 8) (61). MIAF, mESE, and the Cortical Interruption Detection Algorithm perform a segmentation of the bone and an estimation of the location of the cortical break.…”

Section: Quantitative Evaluation Of Erosions From Hr-pqct Imagingmentioning

confidence: 99%

“…Forty-six publications characterizing erosions or cortical breaks/interruptions were found. Erosions have been assessed in a variety of arthritic conditions including early inflammatory arthritis ( 3 , 33 , 37 , 53 , 58 , 59 , 67 ), RA ( 1 , 3 – 7 , 9 , 10 , 12 , 15 , 23 , 26 , 28 – 30 , 34 , 39 , 40 , 44 , 46 – 48 , 52 , 54 , 55 , 61 , 64 , 65 , 67 ), PsA ( 5 , 7 , 14 , 49 , 61 , 66 , 69 ), and erosive hand OA ( 21 ), as well as healthy controls ( 3 , 5 , 7 , 16 , 33 , 39 , 40 , 44 , 45 , 52 , 54 , 55 , 60 , 61 , 64 , 67 ) and subjects with ACPA antibodies but no features of arthritis ( 32 , 50 , 62 ).…”

Section: Pathologymentioning

confidence: 99%

“…As a result of the high spatial resolution and 3D imaging, accurate quantification of erosion size is possible. Several published methods exist, including semiquantitative scores ( 1 , 4 , 16 ), manual measures of the maximal dimension of width and depth ( 5 , 7 , 15 , 30 , 46 , 48 , 58 ), sphericity ( 23 , 29 ), and surface area ( 23 , 52 , 64 ). Erosion volume is the most commonly used method due to the ability to detect changes (progression or repair) in three dimensions.…”

Section: Pathologymentioning

confidence: 99%

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High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

et al. 2020

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High resolution peripheral quantitative computed tomography (HR-pQCT) is a 3-dimensional imaging modality with superior sensitivity for bone changes and abnormalities. Recent advances have led to increased use of HR-pQCT in inflammatory arthritis to report quantitative volumetric measures of bone density, microstructure, local anabolic (e.g., osteophytes, enthesiophytes) and catabolic (e.g., erosions) bone changes and joint space width. These features may be useful for monitoring disease progression, response to therapy, and are responsive to differentiating between those with inflammatory arthritis conditions and healthy controls. We reviewed 69 publications utilizing HR-pQCT imaging of the metacarpophalangeal (MCP) and/or wrist joints to investigate arthritis conditions. Erosions are a marker of early inflammatory arthritis progression, and recent work has focused on improvement and application of techniques to sensitively identify erosions, as well as quantifying erosion volume changes longitudinally using manual, semi-automated and automated methods. As a research tool, HR-pQCT may be used to detect treatment effects through changes in erosion volume in as little as 3 months. Studies with 1-year follow-up have demonstrated progression or repair of erosions depending on the treatment strategy applied. HR-pQCT presents several advantages. Combined with advances in image processing and image registration, individual changes can be monitored with high sensitivity and reliability. Thus, a major strength of HR-pQCT is its applicability in instances where subtle changes are anticipated, such as early erosive progression in the presence of subclinical inflammation. HR-pQCT imaging results could ultimately impact decision making to uptake aggressive treatment strategies and prevent progression of joint damage. There are several potential areas where HR-pQCT evaluation of inflammatory arthritis still requires development. As a highly sensitive imaging technique, one of the major challenges has been motion artifacts; Klose-Jensen et al. HR-pQCT for Inflammatory Rheumatic Disease motion compensation algorithms should be implemented for HR-pQCT. New research developments will improve the current disadvantages including, wider availability of scanners, the field of view, as well as the versatility for measuring tissues other than only bone. The challenge remains to disseminate these analysis approaches for broader clinical use and in research.

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Section: Quantitative Evaluation Of Erosions From Hr-pqct Imagingmentioning

confidence: 89%

Section: Quantitative Evaluation Of Erosions From Hr-pqct Imagingmentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

See 2 more Smart Citations

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

et al. 2020

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“…The diagnosis of erosions and their quantification as part of radiographic scoring systems is an accepted surrogate biomarker of structural progression of arthritis [4,5]. Erosions in RA have been defined in consensus statements and in studies with high-resolution peripheral quantitative computed tomography (HRpqCT) as cortical defects, breaks, or other discontinuities with underlying trabecular bone loss and characteristic locations that can be identified with imaging [6][7][8][9][10][11][12]. diseases, clinical studies comparing therapeutic measurements in RA, studies comparing the sensitivity of imaging modalities without report of false positive diagnosed erosions or erosion-like lesions, surgical procedures or longitudinal studies without direct reference to this topic, case reports and conference papers.…”

Section: Introductionmentioning

confidence: 99%

Pseudoerosions of Hands and Feet in Rheumatoid Arthritis: Anatomic Concepts and Redefinition

Hirtler

Rath

Platzgummer

et al. 2019

JCM

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Rheumatoid arthritis is a chronic inflammatory disease characterized by the development of osseous and cartilaginous damage. The correct differentiation between a true erosion and other entities—then often called “pseudoerosions”—is essential to avoid misdiagnosing rheumatoid arthritis and to correctly interpret the progress of the disease. The aims of this systematic review were as follows: to create a definition and delineation of the term “pseudoerosion”, to point out morphological pitfalls in the interpretation of images, and to report on difficulties arising from choosing different imaging modalities. A systematic review on bone erosions in rheumatoid arthritis was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following search terms were applied in PubMed and Scopus: “rheumatoid arthritis”, “bone erosion”, “ultrasonography”, “radiography”, “computed tomography” and “magnetic resonance imaging”. Appropriate exclusion criteria were defined. The systematic review registration number is 138826. The search resulted ultimately in a final number of 25 papers. All indications for morphological pitfalls and difficulties utilizing imaging modalities were recorded and summarized. A pseudoerosion is more than just a negative definition of an erosion; it can be anatomic (e.g., a normal osseous concavity) or artefact-related (i.e., an artificial interruption of the calcified zones). It can be classified according to their configuration, shape, content, and can be described specifically with an anatomical term. “Calcified zone” is a term to describe the deep components of the subchondral, subligamentous and subtendinous bone, and may be applied for all non-cancellous borders of a bone, thus representing a third type of the bone matrix beside the cortical and the trabecular bone.

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An Update on Imaging in Rheumatoid Arthritis

Isbel

Paramalingam

Conaghan

et al. 2020

Curr Treat Options in Rheum

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Precision and sources of variability in the assessment of rheumatoid arthritis erosions by HRpQCT

Cited by 11 publications

References 34 publications

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

Pseudoerosions of Hands and Feet in Rheumatoid Arthritis: Anatomic Concepts and Redefinition

An Update on Imaging in Rheumatoid Arthritis

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