Precision and Test-Retest Repeatability of Stiffness Measurement with                     MR Elastography: A Multicenter Phantom Study

Ozkaya, Efe; Kennedy, Paul; Chen, Jun; Bane, Octavia; Dillman, Jonathan R.; Jhaveri, Kartik S.; Ohliger, Michael A.; Rossman, Phillip J.; Tkach, Jean A.; Doucette, John T.; Venkatesh, Sudhakar K.; Ehman, Richard L.; Taouli, Bachir

doi:10.1148/radiol.233136

Radiology

2024

DOI: 10.1148/radiol.233136

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Precision and Test-Retest Repeatability of Stiffness Measurement with MR Elastography: A Multicenter Phantom Study

Efe Ozkaya,

Paul Kennedy,

Jun Chen

et al.

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Cited by 5 publications

References 33 publications

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Mechanically anisotropic phantoms for magnetic resonance elastography

Eckstein,

Yoon,

Ruding

et al. 2024

Magnetic Resonance in Med

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PurposeImaging phantoms with known anisotropic mechanical properties are needed to evaluate magnetic resonance elastography (MRE) methods to estimate anisotropic parameters. The aims of this study were to fabricate mechanically anisotropic MRE phantoms, characterize their mechanical behavior by direct testing, then assess the accuracy of MRE estimates of anisotropic properties using a transversely isotropic nonlinear inversion (TI‐NLI) algorithm.MethodsDirectionally scaled and unscaled lattices were designed to exhibit anisotropic or isotropic mechanical properties. Lattices were three‐dimensionally printed in poly(ethelyne glycol) diacrylate using a commercial digital light processing printer, then infilled with gelatin to form a composite material. Benchtop testing determined two shear stiffnesses, and , governing loading parallel and perpendicular to the symmetry axis, and two analogous Young's moduli and . From these measures, shear anisotropy = and tensile anisotropy = were calculated. Three phantoms were driven by a central actuator and imaged with MRE at frequencies from 300 to 500 Hz. From MRE data, the TI‐NLI algorithm estimated maps of , , and .ResultsIn benchtop tests, geometrically scaled lattice composites exhibited the following anisotropic properties: = 6.1 ± 0.7 kPa, = 0.83 ± 0.13, = 0.78 ± 0.09} (mean ± standard deviation). MRE of scaled lattice composites revealed elliptical wavefields; TI‐NLI analysis identified the following median property ranges: = 11–19 kPa, = 0.6–1.0, = 0.8–1.6}.ConclusionAnisotropic MRE phantoms are created by embedding anisotropic three‐dimensionally printed lattices into a softer matrix. The TI‐NLI algorithm accurately estimates spatial contrast in anisotropic properties.

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Mechanically anisotropic phantoms for magnetic resonance elastography

Eckstein,

Yoon,

Ruding

et al. 2024

Magnetic Resonance in Med

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Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles

Wu,

Xu,

Gao

et al. 2024

Eur J Nucl Med Mol Imaging

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Staging Chronic Hepatitis B Related Liver Fibrosis with Diffusion-weighted MRI-based Virtual Elastography: Comparisons with Serum Fibrosis Indexes

Yang,

Zhou,

Liu

et al. 2025

Clinical Radiology

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Precision and Test-Retest Repeatability of Stiffness Measurement with MR Elastography: A Multicenter Phantom Study

Cited by 5 publications

References 33 publications

Mechanically anisotropic phantoms for magnetic resonance elastography

Mechanically anisotropic phantoms for magnetic resonance elastography

Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles

Staging Chronic Hepatitis B Related Liver Fibrosis with Diffusion-weighted MRI-based Virtual Elastography: Comparisons with Serum Fibrosis Indexes

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