Precision biomarkers for mood disorders based on brain imaging

Chen, Runsen; Cui, Zaixu; Capitão, Liliana P; Wang, Gang; Satterthwaite, Theodore D.; Harmer, C J

doi:10.1136/bmj.m3618

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…Further investigation of the mechanisms of brain diseases may indicate approaches to treatment and improve brain function. Brain imaging based cognitive neuroscience may unravel the underlying brain mechanism of cognitive dysfunction and provide an avenue to develop a biological framework for precision biomarkers of mood disorders 13…”

Section: Opportunities and Challenges Of Future Research On Brain Healthmentioning

confidence: 99%

What is brain health and why is it important?

Wang

Pan

2020

BMJ

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Section: Opportunities and Challenges Of Future Research On Brain Healthmentioning

confidence: 99%

What is brain health and why is it important?

Wang

Pan

2020

BMJ

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“…In the light of those findings, one could expect similarities in neuroimaging findings for mood disorders and KLS. However, neuroimaging findings in depression (20), and other mood disorders (21), differ significantly from those reported in KLS (22). However, some clinical features of KLS are similar to those of bipolar disorder and to a lesser extent, schizophrenia.…”

Section: Clinical Psychiatric Features In Klsmentioning

confidence: 80%

Kleine Levin Syndrome: Is it just a sleep disorder? A review of psychiatric features during symptomatic and asymptomatic periods

Gadoth

2023

MRAJ

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Kliene Levin syndrome (KLS) is a peculiar sleep disorder of youth, consisting of idiopathic periodic hypersomnia attacks associated with behavioral and sometimes psychiatric symptoms during an attack. With the growing awareness of the syndrome and a steep rise in published cases, it became evident that psychiatric abnormalities may be present before the onset of hypersomnic events, in between events and first appear following years after complete recovery. Those observations suggest that psychiatric morbidity may be part of the symptomatology of KLS. In the present paper the results of a systematic literature search of publications using the key words KLS with psychiatric features, Atypical KLS, KLS like, KLS mimic and sleeping beauty syndrome will be discussed, in attempt to support the view that KLS is indeed a neuropsychiatric disorder and not just a sleep disorder of youth. Moreover, the recognition that KLS might imitate psychosis and other psychiatric disorders in which periodic hypersomnia is present, may decrease the number of KLS patients in whom the correct diagnosis may be delayed or totally missed.

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“…In recent decades, neuroscience on mood and anxiety disorders has tried to identify biomarkers for diagnosis, prediction of treatment outcome, and treatment development [ 6 , 7 ]. Research has focused on the neural correlates of each of these mental pathologies with their symptomatology and some proposed etiologies such as emotional (dys)regulation.…”

Section: Introductionmentioning

confidence: 99%

A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology

Gonzalez‐García

Visser

2023

Healthcare

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Over the last two decades, the functional role of the bilateral anterior temporal lobes (bATLs) has been receiving more attention. They have been associated with semantics and social concept processing, and are regarded as a core region for depression. In the past, the role of the ATL has often been overlooked in semantic models based on functional magnetic resonance imaging (fMRI) due to geometric distortions in the BOLD signal. However, previous work has unequivocally associated the bATLs with these higher-order cognitive functions following advances in neuroimaging techniques to overcome the geometric distortions. At the same time, the importance of the neural basis of conceptual knowledge in understanding mood disorders became apparent. Theoretical models of the neural basis of mood and anxiety disorders have been classically studied from the emotion perspective, without concentrating on conceptual processing. However, recent work suggests that the ATL, a brain region underlying conceptual knowledge, plays an essential role in mood and anxiety disorders. Patients with anxiety and depression often cope with self-blaming biases and guilt. The theory is that in order to experience guilt, the brain needs to access the related conceptual information via the ATL. This narrative review describes how aberrant interactions of the ATL with the fronto–limbic emotional system could underlie mood and anxiety disorders.

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Precision biomarkers for mood disorders based on brain imaging

Abstract: Identification of biomarkers could facilitate earlier diagnosis and better treatment, say Runsen Chen and colleagues chological model could be harnessed to predict treatment outcomes

Cited by 5 publications

References 38 publications

What is brain health and why is it important?

What is brain health and why is it important?

Kleine Levin Syndrome: Is it just a sleep disorder? A review of psychiatric features during symptomatic and asymptomatic periods

A Semantic Cognition Contribution to Mood and Anxiety Disorder Pathophysiology

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