Precision care for Barrett’s esophagus

Triadafilopoulos, George; Friedland, Shai

doi:10.21037/tgh.2018.09.10

Cited by 9 publications

(11 citation statements)

References 55 publications

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“…У 21 пациента (61,8 %) выявлен длинный сегмент метаплазии СОП (более 3 см). В литературе отмечено, что длинный сегмент метаплазии СОП является более «агрессивным», чем короткий, и чаще приводит к развитию аденокарциномы пищевода [4,7].…”

Section: результаты и обсуждениеunclassified

“…Восстановление функции пищеводно-желудочного перехода с использованием фундопликационной манжеты не элиминирует эктопию слизистой оболочки пищевода, однако способствует устранению патологического желудочно-пищеводного рефлюкса, что в дальнейшем позволяет выполнять эндоскопическое лечение на невоспаленной слизистой оболочке пищевода [7].…”

Section: результаты и обсуждениеunclassified

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Complex approach in diagnostics and treatment of gastroesophageal reflux disease complicated by metaplasia of the esophagus

Cherkasov¹,

Cherkasov²,

Гаджиевна³

et al. 2022

Medical news of the North Caucasus

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rostov state medical university, rostov-on-Don, russian federationПроанализированы результаты лечения 34 пациентов с гастроэзофагеальной рефлюксной болезнью (ГЭРБ), осложненной метаплазией слизистой оболочки пищевода. У 19 (55,9 %) пациентов выявлена кишечная метаплазия, у 9 (26,5 %) -желудочная метаплазия, в 6 случаях -дисплазия низкой степени на фоне кишечной (4) и желудочной (2) метаплазии. После верификации диагноза, консервативной терапии и антирефлюксной операции выполнялась аргон-плазменная коагуляция в зависимости от максимальной длины циркулярного сегмента метаплазии. Осложнений, связанных с процедурой, отмечено не было. В отдаленном периоде у всех пациентов отмечалась регенерация участков метаплазии здоровой тканью. За 6 лет наблюдений ни у одного больного не выявлено рецидивов. Основой успешного лечения ГЭРБ, осложненной метаплазией слизистой оболочки пищевода, является комплексный подход, а разработанная методика аргон-плазменной коагуляции позволяет избежать стриктур пищевода и добиться регресса метаплазии. Ключевые слова: гастроэзофагельная рефлюксная болезнь, рефлюкс-эзофагит, метаплазия пищевода, пищевод БарреттаThe treatment results of 34 patients with GERD complicated by metaplasia of the esophageal mucosa were analyzed. According to the pathomorphological conclusion, 19 (55.9 %) had intestinal metaplasia, in 9 (26.5 %) founded gastric metaplasia, in the remaining 6 cases -low-grade dysplasia against the background of intestinal (4) and gastric (2) metaplasia. After provided diagnosis verification, conservative therapy and antireflux surgery, the patient underwent argon-plasma coagulation, depended from the maximum length of the circular segment of metaplasia. There were no complications, associated with argon-plasma coagulation procedures. In the long-term period, all patients showed regeneration of metaplasia areas with healthy tissue. In observation during 6 years, there were no patient had a relapse of the disease. The basis for the successful treatment is an integrated approach, and the developed technique of argon-plasma coagulation, that allows to avoid the esophageal strictures and to achieve the regression of metaplasia of the esophageal mucosa.

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Section: результаты и обсуждениеunclassified

Complex approach in diagnostics and treatment of gastroesophageal reflux disease complicated by metaplasia of the esophagus

Cherkasov¹,

Cherkasov²,

Гаджиевна³

et al. 2022

Medical news of the North Caucasus

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“…The eradication strategy should be a multimodal therapeutic approach that includes endoscopic ablation and antireflux surgery, and if successfully implemented, it may avoid the need for continuous surveillance that has been shown to have little effect in preventing EAC. 109,110 However, in practice, the outcome is not as ideal as one might expect it to be, and challenges include the quality of the endoscopic eradication strategy. 111 Although level I evidence already exists for radiofrequency ablation (RFA) in both LGD and HGD, 112 no convincing long-term data exist in support of RFA for nondysplastic BE.…”

Section: Prevention Of Eac and Histologic Stabilization By Endoscopicmentioning

confidence: 99%

Clinical course of gastroesophageal reflux disease and impact of treatment in symptomatic young patients

Bonavina

Fisichella

Gavini

et al. 2020

Annals of the New York Academy of Sciences

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In symptomatic young patients with gastroesophageal reflux symptoms, early identification of progressive gastroesophageal reflux disease (GERD) is critical to prevent long‐term complications associated with hiatal hernia, increased esophageal acid and nonacid exposure, release of proinflammatory cytokines, and development of intestinal metaplasia, endoscopically visible Barrett's esophagus, and dysplasia leading to esophageal adenocarcinoma. Progression of GERD may occur in asymptomatic patients and in those under continuous acid‐suppressive medication. The long‐term side effects of proton‐pump inhibitors, chemopreventive agents, and radiofrequency ablation are contentious. In patients with early‐stage disease, when the lower esophageal sphincter function is still preserved and before endoscopically visible Barrett's esophagus develops, novel laparoscopic procedures, such as magnetic and electric sphincter augmentation, may have a greater role than conventional surgical therapy. A multidisciplinary approach to GERD by a dedicated team of gastroenterologists and surgeons might impact the patients’ lifestyle, the therapeutic choices, and the course of the disease. Biological markers are needed to precisely assess the risk of disease progression and to tailor surveillance, ablation, and management.

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“…Esophagus carcinoma staging and management can be effectively diagnosed with radio imaging modality like MDCT (multidetector computed tomography) which offers esophagus carcinoma severity with clear demonstration. It is also capable of identifying distant metastasis provides aids to clinicians for conceiving proper treatment and planning [13]. The present study aims was to assess the computerized tomography scan (CT scan) role in distinguishing esophageal cancer staging.…”

Section: Introductionmentioning

confidence: 99%

Role of Ct Imaging and Staging of Esophgus Carcinoma

Lodhi¹,

Rizwan²,

Akram³

2021

PJMHS

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Background and Aim: Esophageal carcinoma is the 8thmost common type of cancer worldwide and is considered a leading cause of cancer mortality. Cancer of the esophagus is one of the most lethal of all cancers. The esophagus is clearly visible on CT images. Over the last decade, computerized tomography (CT) tools have qualified the carcinoma early finding, thereby lowering mortality rates. The advent of multidetector computerized tomography (MDCT) scanners has been a boon to clinical imaging practice. The aim of the present study was to assess the role of computed tomography imaging in esophagus carcinoma staging and detection. Materials and Methods: This prospective study was conducted on 82 esophagus carcinoma patients in the department of Radiology, Sir Ganga Ram Hospital Lahore from July 2020 to June 2021. Individuals who presented with esophagus carcinoma signs and symptoms were enrolled in this study. Esophagus carcinoma was confirmed based on histopathological examination (HPE) reports and postoperative biopsy confirmed the CT findings. Data analysis was done with SPSS version 20. Results: Of the total 82 esophagus carcinoma patients, 44 (54%) were male and 38 (46%) were female. The overall mean age was 45.53±7.3 years with an age range from 18 years to 80 years. The incidence of esophagus carcinoma was more prevalent in the age group of 40 to 60 years. Male patients are more prone to esophagus carcinoma compared to females. The carcinoma in most cases affected the esophagus lower third and middle compared to the upper third. The prevalence of stage patients was as follows; T1 and T2 had 22 (26.8%) stage patients, T3 had 46 (56.1%) stage patients, and T4 had 14 (17.1%). About 52 (64%) patients had asymmetrical wall thickness while 30 (36%) had symmetrical wall thickness. Conclusion: Preoperative esophageal carcinoma staging is significantly aided by computed tomography. Imaging modality CT scans have improved esophageal carcinoma treatment and operative resection rate. As a result, CT is a non-invasive and quick imaging tool for detecting lymphadenopathies, distant metastases, and tumors. Keywords: Esophagus carcinoma; Staging; CT scan; Multidetector computerized tomography

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Precision care for Barrett’s esophagus

Cited by 9 publications

References 55 publications

Complex approach in diagnostics and treatment of gastroesophageal reflux disease complicated by metaplasia of the esophagus

Complex approach in diagnostics and treatment of gastroesophageal reflux disease complicated by metaplasia of the esophagus

Clinical course of gastroesophageal reflux disease and impact of treatment in symptomatic young patients

Role of Ct Imaging and Staging of Esophgus Carcinoma

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