Precision medicine, which customizes healthcare based on individual genetic, environmental, and lifestyle factors, has significantly advanced various medical fields. However, its adoption in emergency medicine remains limited despite the potential to enhance patient outcomes through more accurate diagnostics and personalized treatments. This systematic review examined current evidence on the application of precision medicine in emergency care by analyzing studies published between 2010 and 2024. Out of 218 records, 10 studies met the inclusion criteria, highlighting areas such as genomic applications, machine learning, pointof-care diagnostics, and biomarkers. The findings indicate that precision medicine can improve diagnostic accuracy and personalize patient care in emergency settings, although challenges such as time constraints, technological limitations, and the need for enhanced clinician training remain. Overcoming these barriers through interdisciplinary collaboration, investment in rapid diagnostic technologies, and comprehensive education programs is essential for effectively integrating precision medicine into emergency care. Ultimately, advancing precision emergency medicine holds promise for transforming emergency care into a more personalized and effective practice, thereby improving patient outcomes in acute situations.