Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

Gao, Peng; Shen, Xiaotao; Zhang, Xinyue; Jiang, Chao; Zhang, Sai; Zhou, Xin; Rose, Sophia Miryam Schüssler‐Fiorenza; Snyder, M

doi:10.1101/gr.276521.121

Cited by 39 publications

(32 citation statements)

References 74 publications

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“…">A multidimensional and interdisciplinary approach is needed to investigate how external environmental exposures are translated into internal exposures and responses, disturbing molecular interactions at the DNA, RNA, protein, and metabolite levels, leading to corresponding health outcomes. A recent study attempted to integrate the personal external and internal exposome and investigated the health outcome of individuals using multiomics [24]. The recent decade's translational achievements of microbiome research set an excellent example for this goal. …”

Section: Outstanding Challengesmentioning

confidence: 99%

Charting the landscape of the environmental exposome

Wei

Huang

Jiang

et al. 2022

iMeta

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The exposome depicts the total exposures in the lifetime of an organism. Human exposome comprises exposures from environmental and humanistic sources. Biological, chemical, and physical environmental exposures pose potential health threats, especially to susceptible populations. Although still in its nascent stage, we are beginning to recognize the vast and dynamic nature of the exposome. In this review, we systematically summarize the biological and chemical environmental exposomes in three broad environmental matrices—air, soil, and water; each contains several distinct subcategories, along with a brief introduction to the physical exposome. Disease‐related environmental exposures are highlighted, and humans are also a major source of disease‐related biological exposures. We further discuss the interactions between biological, chemical, and physical exposomes. Finally, we propose a list of outstanding challenges under the exposome research framework that need to be addressed to move the field forward. Taken together, we present a detailed landscape of environmental exposome to prime researchers to join this exciting new field.

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Section: Outstanding Challengesmentioning

confidence: 99%

Charting the landscape of the environmental exposome

Wei

Huang

Jiang

et al. 2022

iMeta

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“…An increasing number of personal sensors are being developed to monitor heart rate, blood sugar concentrations, blood pressure, muscle activity, temperature, and sweat production [98]. Remarkable advances in novel algorithms in wearable technologies are allowing for accurate acquisition of personal temperature exposures, chemical and biological exposures, and clinical laboratory measurements to explore individual-level 24-h exposures in various microenvironments in exposome studies [99][100][101][102]. Koelmel et al captured the changes in gas-and particulate-phase airborne chemicals to which individuals were exposed and determined which exposures posed the greatest risk to health.…”

Section: Individual-level Exposures Portable/personal Sampling and Se...mentioning

confidence: 99%

“…Next-generation sequencing and liquid chromatography‒mass spectrometry (LC‒MS) technologies were then used to detect the biotic/chemical exposome and found that the human exposome was dynamic and influenced by various environmental and spatial/lifestyle variables. Gao et al examined the effects of environmental exposures on well-dissected personal internal health changes based on longitudinal individual exposomes and internal multiomics (gut microbiome, proteome and metabolome) [ 101 ]. By investigating the correlations of exposomics and the exposome and clinical data, it was found that changes in external exposures could be associated with thousands of biomolecular changes in the body involved in immune, kidney, and liver functions.…”

Section: Exposomic Measurement Tools For Use In Age-related Disease S...mentioning

confidence: 99%

A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases

et al. 2022

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Age-related diseases account for almost half of all diseases among adults worldwide, and their incidence is substantially affected by the exposome, which is the sum of all exogenous and endogenous environmental exposures and the human body’s response to these exposures throughout the entire lifespan. Herein, we perform a comprehensive review of the epidemiological literature to determine the key elements of the exposome that affect the development of age-related diseases and the roles of aging hallmarks in this process. We find that most exposure assessments in previous aging studies have used a reductionist approach, whereby the effect of only a single environmental factor or a specific class of environmental factors on the development of age-related diseases has been examined. As such, there is a lack of a holistic and unbiased understanding of the effect of multiple environmental factors on the development of age-related diseases. To address this, we propose several research strategies based on an exposomic framework that could advance our understanding—in particular, from a mechanistic perspective—of how environmental factors affect the development of age-related diseases. We discuss the statistical methods and other methods that have been used in exposome-wide association studies, with a particular focus on multiomics technologies. We also address future challenges and opportunities in the realm of multidisciplinary approaches and genome–exposome epidemiology. Furthermore, we provide perspectives on precise public health services for vulnerable populations, public communications, the integration of risk exposure information, and the bench-to-bedside translation of research on age-related diseases.

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“…Altogether, these data emphasized that environmental diseases are a crucial issue in the current literature, with growing attention to the international policies targeting environmental modification to improve global health [ 2 ]. In this scenario, several environmental factors might be associated with human health and might be effectively targeted by precise environmental strategies [ 19 ]. However, environmental modifications might have a crucial impact not only on global health but also on functional impairment.…”

Section: Environmental Diseasesmentioning

confidence: 99%

Environmental Factors in the Rehabilitation Framework: Role of the One Health Approach to Improve the Complex Management of Disability

Lippi

Sire

Folli

et al. 2022

IJERPH

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Environment factors play a crucial implication in human health, with strong evidence suggesting that several biological, chemical, physical and social factors could be possible targets to implement effective strategies for human health promotion. On the other hand, a large gap of knowledge still exists about the implications of environmental factors in terms of functional impairment and disability, while the integration of an environmental-based approach in the therapeutic care of patients affected by disabilities remains still challenging. In this scenario, the One Health approach has been recently introduced in clinical care and aims to optimize health outcomes by recognizing the interconnection between people and the environment. Concurrently, the “Rehabilitation 2030 Initiative” proposed in 2017 by the WHO emphasized the need to integrate environmental-based strategies to promote rehabilitation across different health systems and different nations. However, no previous study underlined the potential implications of the One Health approach in the rehabilitation setting, nor the role of a comprehensive rehabilitation approach focused on environmental factors. Therefore, the aim of this narrative review was to present a comprehensive overview of the data currently available assessing the close relationship between rehabilitation and the environment to provide a different perspective on the comprehensive care of patients affected by disability.

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Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

Cited by 39 publications

References 74 publications

Charting the landscape of the environmental exposome

Charting the landscape of the environmental exposome

A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases

Environmental Factors in the Rehabilitation Framework: Role of the One Health Approach to Improve the Complex Management of Disability

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