Precision immunization: a new trend in human vaccination

Jia, Siyue; Li, Jingxin; Liu, Yuanbao; Zhu, Fengcai

doi:10.1080/21645515.2019.1670123

Cited by 11 publications

(13 citation statements)

References 85 publications

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“…Developing universal and safe vaccines that boost immunity and induce effective neutralizing antibodies and memory cells against a wide range of pathogenic structures [eg, envelope glycosylated proteins or glycoproteins (hemagglutinine-rich structures), mannosyl-rich proteins, glycolipids and related enzymes and receptor molecules] are yet to be seriously considered. Recent attempts toward 'universal' flu vaccines, while provide useful additional information and insights into shared or special structural and sub-structural characteristics or compatibility among a few pathogens (eg, HIV, influenza) and the relation to host receptor glycoproteins and induction of immune responses (eg, IgGs) they are far from being considered as universal vaccines or safer treatment options 1,32,86,96,136,[210][211][212] (manuscript in preparation). Such efforts for making a vaccine against pathogenic components of one infective family structure (eg, flu, SARS, or covid-19) should not be claimed as 'universal'.…”

Section: Toward Universal and Safe Vaccine Development: Timely Challementioning

confidence: 99%

“…The concept of vaccination, or rather immunization, for protecting, promoting and defending individual health against viruses, bacteria or parasites developed in the eighteenth century, well before the important theory of immune surveillance was developed, and before better hygiene or antibiotics improved public health and reduced many preventable infectious diseases and increased longevity. The concept of protecting public health by immunization also existed before Rockefeller patent medicine and Gates patent vaccines invested a great deal in medical education to influence promotion of drug sale and to vaccinate the public with pathogen‐specific vaccines in toxic media and associated debates and controversies 1,2,4,5,12,13,17,18,20‐24,28,30‐33,36‐40,59‐63,66‐68,70,73,77,83,93,94,96,97,110,111,116,128,136‐144,146‐150,156,158,160‐166,168‐172,174,175,181,189‐197,205,206,212 …”

Section: Vaccine Sciences: Current Immunological Safety Concernsmentioning

confidence: 99%

“…Integration of the scattered data on epidemiological, environmental, clinical and basic research on developmental biology, inflammatory diseases, cancer and vaccine sciences, treatment options are outlined below 1‐14,17,24,50,71,82,86,93,119,120,128,136,150‐153,155,156,176,177,182‐185,203‐207,209‐218,220 , , , :…”

Section: Twentieth Century Medicine: Shifting Disease Categories To Imentioning

confidence: 99%

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Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Khatami

2020

Clinical & Translational Med

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Schematic representation of cause, exacerbation and consequence of vaccinesinduced diverse immune disorders in immune-responsive or immune-privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblastembryo-fetus-placenta and orderly growth and development affecting epithelialmesenchymal transition, proper expression of constituent-inducible receptor molecules; consequently influence immunity of newborn, infant, children and adults. Vaccine-induced impaired organ development and immunity include impaired mitochondrial function (mitophagy), tissue bioenergetics, loss of balance in Yin (tumoricidal) and Yang (tumorigenic) pathways and altered metabolic-neuronal-hormonal activities as bases for increased induced diseases in young and old.

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Section: Toward Universal and Safe Vaccine Development: Timely Challementioning

confidence: 99%

Section: Vaccine Sciences: Current Immunological Safety Concernsmentioning

confidence: 99%

Section: Twentieth Century Medicine: Shifting Disease Categories To Imentioning

confidence: 99%

See 1 more Smart Citation

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Khatami

2020

Clinical & Translational Med

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“…Besides, the effect of maternal poliovirus antibodies on the antibody persistence of IPV vaccination may be needed to be observed in long term, and we will take this as a potential focus of our subsequent work. In the future, maternal antibody will be an important factor to be considered in achieving precision immunization in infants [21].…”

Section: Discussionmentioning

confidence: 99%

The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines

Jia

Tang

et al. 2020

BMC Infect Dis

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Background: Maternal poliovirus antibodies could provide passive immunity to the newborns from poliovirus infection during their first few months of life, but they may impair the immune responses of infants to the poliovirus vaccine as well. In our study, we pooled the data from three clinical trials of the inactivated poliovirus vaccine (IPV) based on Sabin strains to investigate the effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines. Methods: There were five groups in the pooled analysis, including low-dose Sabin IPV, medium-dose Sabin IPV, high-dose Sabin IPV, control Sabin IPV, and control Salk IPV groups. We reclassified the infants in different groups according to their maternal poliovirus antibodies by two methods, the first one included maternal antibody negative (< 1:8) and maternal antibody positive (≥1:8), and the second one included maternal antibody titer < 1:8, 1:8~< 1:32 and ≥ 1:32. Then, we compared the geometric mean titers (GMTs), geometric mean antibody fold increases (GMIs) and seroconversion rates of poliovirus type-specific neutralizing antibodies after vaccination among participants with different maternal poliovirus antibody levels. Results: The GMTs and GMIs of three types of poliovirus antibodies after vaccination in maternal antibody negative participants were significantly higher than those in maternal antibody positive participants. The seroconversion rates of type II and type III poliovirus antibodies in maternal antibody positive participants were significantly lower than those in maternal antibody negative participants. Among participants with maternal antibody titer < 1:8, 1:8~< 1:32 and ≥ 1:32, the GMTs and GMIs of three types of poliovirus antibodies after vaccination showed a tendency to decline with the increasing of maternal antibody levels. The seroconversion rates of three types of poliovirus antibodies in participants with maternal antibody titer ≥1:32 were significantly lower than those in participants with maternal antibody titer < 1:8 and 1:8~< 1:32. Conclusions: Maternal poliovirus antibodies interfered with the immune responses of infants to poliovirus vaccines, and a high level of maternal antibodies exhibited a greater dampening effect.

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“…However, there is increasing interest on the use of “ precise vaccination ,” targeting specific subpopulations and tailoring vaccination on a more individual level, taking into account factors such as age, sex, and disease susceptibility. Adjusting formulation, dosage and timing to patient factors could help maximize the effects of vaccination while reducing the risks ( 54 ). In the specific setting of neonates, immunization through vaccination of subpopulations of pregnant women could be an elegant manner to protect the neonate against invasive infections in the first 3 months of life, including bacterial infections.…”

Section: Preventionmentioning

confidence: 99%

Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine

Keij¹,

Achten²,

Tramper-Stranders³

et al. 2021

Front. Pediatr.

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Bacterial infections remain a major cause of morbidity and mortality in the neonatal period. Therefore, many neonates, including late preterm and term neonates, are exposed to antibiotics in the first weeks of life. Data on the importance of inter-individual differences and disease signatures are accumulating. Differences that may potentially influence treatment requirement and success rate. However, currently, many neonates are treated following a “one size fits all” approach, based on general protocols and standard antibiotic treatment regimens. Precision medicine has emerged in the last years and is perceived as a new, holistic, way of stratifying patients based on large-scale data including patient characteristics and disease specific features. Specific to sepsis, differences in disease susceptibility, disease severity, immune response and pharmacokinetics and -dynamics can be used for the development of treatment algorithms helping clinicians decide when and how to treat a specific patient or a specific subpopulation. In this review, we highlight the current and future developments that could allow transition to a more precise manner of antibiotic treatment in late preterm and term neonates, and propose a research agenda toward precision medicine for neonatal bacterial infections.

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Precision immunization: a new trend in human vaccination

Cited by 11 publications

References 85 publications

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines

Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine

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