Precision Nutrition Unveiled: Gene–Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management

Mansour, Samy; Alkhaaldi, Saif M. I.; Sammanasunathan, Ashwin F.; Ibrahim, Saleh; Farhat, Joviana; Al-Omari, Basem

doi:10.3390/nu16050581

Cited by 3 publications

(1 citation statement)

References 195 publications

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“…Bacteria, fragments, and their DNA have been identified in cardiovascular disease patients [ 56 , 57 , 58 , 59 ]. Importantly, LPS from blood bacteria participates in the atherosclerotic process via the formation of macrophage-derived foam cells [ 60 , 61 , 62 ].…”

Section: Dysbiosis Of Blood Microbiota and Disease Outcomementioning

confidence: 99%

Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes

Santacroce,

Charitos,

Colella

et al. 2024

Hematology Reports

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In healthy conditions, blood was considered a sterile environment until the development of new analytical approaches that allowed for the detection of circulating bacterial ribosomal DNA. Currently, debate exists on the origin of the blood microbiota. According to advanced research using dark field microscopy, fluorescent in situ hybridization, flow cytometry, and electron microscopy, so-called microbiota have been detected in the blood. Conversely, others have reported no evidence of a common blood microbiota. Then, it was hypothesized that blood microbiota may derive from distant sites, e.g., the gut or external contamination of blood samples. Alteration of the blood microbiota’s equilibrium may lead to dysbiosis and, in certain cases, disease. Cardiovascular, respiratory, hepatic, kidney, neoplastic, and immune diseases have been associated with the presence of Gram-positive and Gram-negative bacteria and/or their products in the blood. For instance, lipopolysaccharides (LPSs) and endotoxins may contribute to tissue damage, fueling chronic inflammation. Blood bacteria can interact with immune cells, especially with monocytes that engulf microorganisms and T lymphocytes via spontaneous binding to their membranes. Moreover, LPSs, extracellular vesicles, and outer membrane vesicles interact with red blood cells and immune cells, reaching distant organs. This review aims to describe the composition of blood microbiota in healthy individuals and those with disease conditions. Furthermore, special emphasis is placed on the interaction of blood microbiota with host cells to better understand disease mechanisms.

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Section: Dysbiosis Of Blood Microbiota and Disease Outcomementioning

confidence: 99%

Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes

Santacroce,

Charitos,

Colella

et al. 2024

Hematology Reports

View full text Add to dashboard Cite

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Association of body roundness index with female infertility: 2013–2018 NHANES

Wang,

Hou,

Wang

et al. 2024

Front. Nutr.

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AimThis study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals’ well-being and rights.MethodsAll individuals who completed the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2018 were initially included in this cross-sectional study. Following the screening, 2,777 eligible participants were selected for analysis from the original pool of 10,375 participants. Trained operators conducted anthropometric measurements, including height, weight, and waist circumference. The BRI was then calculated based on established research. Data from infertility status questionnaires were gathered from the NHANES database for all participants, with self-reported infertility serving as the study outcome. Multivariable logistic regression and restricted cubic splines (RCS) were employed to investigate the relationship between BRI and infertility. Subgroup analyses were also conducted to further explore the association between BRI and infertility.ResultsUpon analyzing the baseline characteristics of all women in the study, notable distinctions were identified in the clinical and demographic features between fertile and infertile women. Our investigation revealed a positive correlation between BRI and the likelihood of infertility in both weighted and unweighted multiple logistic regression models. Additionally, BRI exhibited a significant association with infertility in both continuous and categorical forms. Utilizing RCS curves, we noted a linear escalation in the prevalence of infertility with rising BRI values. Subgroup analyses provided further clarity on these observations.ConclusionOur study demonstrates a statistically significant positive correlation between BRI and the prevalence of infertility across diverse populations, suggesting potential implications for infertility prevention and treatment. Future prospective cohort studies will explore this association and understand the underlying mechanisms.

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Unraveling the Gut Microbiota: Implications for Precision Nutrition and Personalized Medicine

Abeltino,

Hatem,

Serantoni

et al. 2024

Nutrients

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Recent studies have shown a growing interest in the complex relationship between the human gut microbiota, metabolism, and overall health. This review aims to explore the gut microbiota–host association, focusing on its implications for precision nutrition and personalized medicine. The objective is to highlight how gut microbiota modulate metabolic and immune functions, contributing to disease susceptibility and wellbeing. The review synthesizes recent research findings, analyzing key studies on the influence of gut microbiota on lipid and carbohydrate metabolism, intestinal health, neurobehavioral regulation, and endocrine signaling. Data were drawn from both experimental and clinical trials examining microbiota–host interactions relevant to precision nutrition. Our findings highlight the essential role of gut microbiota-derived metabolites in regulating host metabolism, including lipid and glucose pathways. These metabolites have been found to influence immune responses and gut barrier integrity. Additionally, the microbiota impacts broader physiological processes, including neuroendocrine regulation, which could be crucial for dietary interventions. Therefore, understanding the molecular mechanisms of dietary–microbiota–host interactions is pivotal for advancing personalized nutrition strategies. Tailored dietary recommendations based on individual gut microbiota compositions hold promise for improving health outcomes, potentially revolutionizing future healthcare approaches across diverse populations.

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Precision Nutrition Unveiled: Gene–Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management

Cited by 3 publications

References 195 publications

Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes

Blood Microbiota and Its Products: Mechanisms of Interference with Host Cells and Clinical Outcomes

Association of body roundness index with female infertility: 2013–2018 NHANES

Unraveling the Gut Microbiota: Implications for Precision Nutrition and Personalized Medicine

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