Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

Avian, Alexander; Mattersberger, Christian; Schober, Lukas; Martensen, Johann; Wolf, Martin; Kamo, Wataru; Pichler, Gerhard; Schwaberger, Bernhard; Urlesberger, Berndt

doi:10.1117/1.nph.8.4.045001

Cited by 4 publications

(15 citation statements)

References 33 publications

(46 reference statements)

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“…This was a secondary outcome analysis. A precision analysis of cerebral oxygen saturation using the same study population and study protocol for analysis has already been published by Avian et al 9 The sample size estimation in Avian et al 9 was performed to analyse the precision of cerebral oxygen saturation obtained by time-resolved NIRS measurements. Sample size calculation was performed using 95% confidence intervals for the precision of measurement of cerebral oxygen saturation.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the importance of precision of measurements of cerebral haemodynamic parameters, several studies described reproducibility of various NIRS oximeters, focusing on cerebral oxygen saturation. [9][10][11][12][13] For CBV there are huge ranges of estimated normal values.…”

Section: Nirsmentioning

confidence: 99%

“…It can be calculated by using the Hb tot , the factor 0.89, representing the cerebral-to-large vessel haematocrit ratio and the concentration of haemoglobin in the blood 7,9,15,16 using the equation:…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

“…Avian et al 9 investigated the precision of cerebral oxygen saturation (time-resolved NIRS) in stable preterm neonates performed by five reapplications. They observed that time-resolved NIRS measurements for cerebral oxygen saturation were precise with a within-patient variation below the threshold of 5%.…”

mentioning

confidence: 99%

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Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy

Wolfsberger,

Avian,

Schwaberger

et al. 2023

Acta Paediatrica

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AimTo investigate cerebral blood volume (CBV) in preterm neonates using time‐resolved near‐infrared spectroscopy.MethodsIn this prospective observational study, time‐resolved near‐infrared spectroscopy measurements of CBV using tNIRS‐1 were performed in 70 preterm neonates. For measurements, a sensor was placed for a duration of 1 min, followed by four further reapplications of the sensor, overall five measurements.ResultsIn this study, 70 preterm neonates with a mean ± SD gestational age of 33.4 ± 1.7 weeks and a birthweight of 1931 ± 398 g were included with a postnatal age of 4.7 ± 2.0 days. Altogether, 2383 CBV values were obtained with an overall mean of 1.85 ± 0.30 mL/100 g brain. A total of 95% of the measured CBV values varied in a range from −0.31 to 0.33 from the overall individual mean. Taking the deviation of the mean of each single application for each patient, this range reduced from −0.07 to 0.07. The precision of the measurement defined as within‐variation in CBV was 0.24 mL/100 g brain.ConclusionThe overall mean CBV in stable preterm neonates was 1.85 ± 0.30 mL/100 g brain. The within‐variation in CBV was 0.24 mL/100 g brain. Based on the precision obtained by our data, CBV of 1.85 ± 0.30 mL/100 g brain may be assumed as normal value for this cohort.

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Section: Discussionmentioning

confidence: 99%

Section: Nirsmentioning

confidence: 99%

Section: Near-infrared Spectroscopymentioning

confidence: 99%

mentioning

confidence: 99%

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Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy

Wolfsberger,

Avian,

Schwaberger

et al. 2023

Acta Paediatrica

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“…The hemodynamic management immediately after birth may have a impact on the ongoing transition from fetal-to-neonatal circulation during the first days and weeks after birth. In this context, the absence of physiologic closure of the ductus arteriosus and the therapeutic regimen of this condition is a "hot topic", especially in premature infants (17)(18)(19). If the ductus arteriosus remains patent after one or two weeks, it may cause severe left-to-right shunting and overloaded pulmonary perfusion resulting in pulmonary edema, pulmonary hypertension, and bronchopulmonary dysplasia (18).…”

Section: Cardio-circulatory Supportmentioning

confidence: 99%

Editorial: Cardio-circulatory support of neonatal transition

Schwaberger

Pichler²,

Baik‐Schneditz³

et al. 2023

Front. Pediatr.

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Reference values for cerebral and peripheral tissue oximetry in children: A clinical TD‐NIRS study

Calcaterra,

Lacerenza,

Rossi

et al. 2024

Acta Paediatrica

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AimCurrent non‐invasive near‐infrared spectroscopy (NIRS) tissue oximetry suffers from suboptimal reproducibility over probe repositioning, hindering clinical threshold establishment. Time Domain‐NIRS (TD‐NIRS) offers higher precision but lacks sufficient paediatric data, preventing effective clinical application. We aimed to establish reference ranges for cerebral and mid‐upper arm (MUA) tissue haemodynamics in paediatric subjects using TD‐NIRS and explore correlations with auxological variables.MethodsTD‐NIRS measurements were conducted acquiring data from cerebral and MUA regions with the NIRSBOX tissue oximeter. Morphological and clinically relevant information were collected to explore potential correlations with TD‐NIRS derived parameters.ResultsTD‐NIRS assessment was applied in 350 children (8.4 ± 5.0 years). Precision of TD‐NIRS was demonstrated with standard deviations of 0.9% (StO2) and 4.2 μM (tHb) for frontotemporal cerebral cortex, and 0.8% (StO2) and 3.7 μM (tHb) for MUA. No user dependency was observed. The trends of values for cerebral and peripheral regions vary differently according to age and auxological parameters.ConclusionThis study reports resting‐state optical and haemodynamic values for a healthy paediatric population, providing a foundation for future investigations into clinically relevant deviations in these parameters. Furthermore, correlations with anthropometric and demographic values provide valuable insights for a deeper understanding of tissue haemodynamic evolution in childhood.

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Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants

Cited by 4 publications

References 33 publications

Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy

Precision and normal values of cerebral blood volume in preterm neonates using time‐resolved near‐infrared spectroscopy

Editorial: Cardio-circulatory support of neonatal transition

Reference values for cerebral and peripheral tissue oximetry in children: A clinical TD‐NIRS study

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