Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study

Jin, Jiale; Wang, Dongyu; Qian, Hu; Ruan, Chengxin; Yang, Yiqi; Li, Dongdong; Wang, Guohua; Zhu, Xiaobo; Hu, Yihe; Lei, Pengfei

doi:10.1016/j.biomaterials.2024.122756

Biomaterials

2025

DOI: 10.1016/j.biomaterials.2024.122756

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Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study

Jiale Jin,

Dongyu Wang,

Hu Qian

et al.

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Cited by 3 publications

References 80 publications

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Bio-functional niobium-based metallic biomaterials: Exploring their physicomechanical properties, biological significance, and implant applications

Liu,

Zhao,

Yin

et al. 2024

Acta Biomaterialia

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Bio-functional niobium-based metallic biomaterials: Exploring their physicomechanical properties, biological significance, and implant applications

Liu,

Zhao,

Yin

et al. 2024

Acta Biomaterialia

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Materials for 3D printing in healthcare sector: A review

Nizam,

Purohit,

Taufik

2024

Proc Inst Mech Eng H

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Additive Manufacturing (AM) encompasses various techniques creating intricate components from digital models. The aim of incorporating 3D printing (3DP) in the healthcare sector is to transform patient care by providing personalized solutions, improving medical procedures, fostering research and development, and ultimately optimizing the efficiency and effectiveness of healthcare delivery. This review delves into the historical beginnings of AM’s 9 integration into medical contexts exploring various categories of AM methodologies and their roles within the medical sector. This survey also dives into the issue of material requirements and challenges specific to AM’s medical applications. Emphasis is placed on how AM processes directly enhance human well-being. The primary focus of this paper is to highlight the evolution and incentives for cross-disciplinary AM applications, particularly in the realm of healthcare by considering their principle, materials and applications. It is designed for a diverse audience, including manufacturing professionals and researchers, seeking insights into this transformative technology’s medical dimensions.

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A Novel Triad of Bio-Inspired Design, Digital Fabrication, and Bio-Derived Materials for Personalised Bone Repair

Dei Rossi,

Vergani,

Buccino

2024

Materials

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The emerging paradigm of personalised bone repair embodies a transformative triad comprising bio-inspired design, digital fabrication, and the exploration of innovative materials. The increasing average age of the population, alongside the rising incidence of fractures associated with age-related conditions such as osteoporosis, necessitates the development of customised, efficient, and minimally invasive treatment modalities as alternatives to conventional methods (e.g., autografts, allografts, Ilizarov distraction, and bone fixators) typically employed to promote bone regeneration. A promising innovative technique involves the use of cellularised scaffolds incorporating mesenchymal stem cells (MSCs). The selection of materials—ranging from metals and ceramics to synthetic or natural bio-derived polymers—combined with a design inspired by natural sources (including bone, corals, algae, shells, silk, and plants) facilitates the replication of geometries, architectures, porosities, biodegradation capabilities, and mechanical properties conducive to physiological bone regeneration. To mimic internal structures and geometries for construct customisation, scaffolds can be designed using Computer-aided Design (CAD) and fabricated via 3D-printing techniques. This approach not only enables precise control over external shapes and internal architectures but also accommodates the use of diverse materials that improve biological performance and provide economic advantages. Finally, advanced numerical models are employed to simulate, analyse, and optimise the complex processes involved in personalised bone regeneration, with computational predictions validated against experimental data and in vivo studies to ascertain the model’s ability to predict the recovery of bone shape and function.

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Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study

Cited by 3 publications

References 80 publications

Bio-functional niobium-based metallic biomaterials: Exploring their physicomechanical properties, biological significance, and implant applications

Bio-functional niobium-based metallic biomaterials: Exploring their physicomechanical properties, biological significance, and implant applications

Materials for 3D printing in healthcare sector: A review

A Novel Triad of Bio-Inspired Design, Digital Fabrication, and Bio-Derived Materials for Personalised Bone Repair

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