Precision strategies for cancer treatment by modifying the tumor-related bacteria

Lu, Huazhen; Wang, Qingzhuo; Liu, Wenzheng; Wen, Zhiqiang; Li, Yanan

doi:10.1007/s00253-021-11491-9

Cited by 13 publications

(14 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Binding pairs, like antigen-antibody and biotin-streptavidin, have been extensively studied. 40,49 In a study conducted by Akolpoglu and colleagues, 50 the biotin-streptavidin binding was employed to create a complex between magnetic materials and radionuclides (mNPs) situated on the surface of E. coli. This bacterial surface was engineered to produce both GFP and biotin.…”

Section: Biotin-streptavidinmentioning

confidence: 99%

Breaking barriers in cancer treatment: nanobiohybrids empowered by modified bacteria and vesicles

Ijaz,

Khurshid,

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

Section: Biotin-streptavidinmentioning

confidence: 99%

Breaking barriers in cancer treatment: nanobiohybrids empowered by modified bacteria and vesicles

Ijaz,

Khurshid,

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…[ 141 ] Substantial evidence indicates that tumors are keen to take up glucose and convert it to lactic acid, which plays an important role in regulating tumor development, progression, and metastasis. [ 80a,142 ] Thus, by interfering with lactate metabolic homeostasis, some bacteria provide opportunities for cancer treatment by their natural lactic acid degradation capacity. For example, the facultative anaerobe, S. oneidensis MR‐1, can selectively substitute lactic acid for glucose as an energy source.…”

Section: Interaction Of Bacteria and Nanomaterials In Cancer Therapymentioning

confidence: 99%

Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Zhou,

Li,

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, and producing anticancer microbial agents in situ to suppress tumor growth. Despite the unique advantages of bacteria‐based cancer biotherapy, the insufficient treatment efficiency limits its application in the complete ablation of malignant tumors. The combination of nanomedicine and engineered bacteria has attracted increasing attention owing to their striking synergistic effects in cancer treatment. Engineered bacteria that act as natural vehicles can effectively deliver nanomedicines to tumor sites. Moreover, bacteria provide an opportunity to enhance nanomedicines by modulating the TME and producing substrates to support nanomedicine‐mediated anticancer reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, and catalytic properties, and plays an important role in promoting bacteria‐mediated biotherapies. The synergistic anticancer effects of engineered bacteria and nanomedicines in cancer therapy are comprehensively summarized in this review. Attention is paid not only to the fabrication of nanobiohybrid composites, but also to the interpromotion mechanism between engineered bacteria and nanomedicine in cancer therapy. Additionally, recent advances in engineered bacteria‐synergized multimodal cancer therapies have also been highlighted.This article is protected by copyright. All rights reserved

show abstract

“…Gut microbes can populate tumors because the hypoxic nature of the tumor microenvironment is suitable for many gut inhabitants. They can enter the tumor directly from the bloodstream because of leaky blood vessels, or they can be brought there by leukocytes (Lu et al 2021 ; Berg and Garlington 1979 ; Rescigno et al 2001 ). A typical intestinal pathogen can translocate from the intestine through M cells (transcellular pathway, such as S. flexneri ) or breach the integrity of the intestinal barrier (paracellular pathway, such as Salmonella enterica serovar Typhimurium) (Rey et al 2020 ; Sun et al 2020 ).…”

Section: Distant Effects Of Gut Microbiotamentioning

confidence: 99%

Microbiota as the unifying factor behind the hallmarks of cancer

Benešová

Křížová

Kverka

2023

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

The human microbiota is a complex ecosystem that colonizes body surfaces and interacts with host organ systems, especially the immune system. Since the composition of this ecosystem depends on a variety of internal and external factors, each individual harbors a unique set of microbes. These differences in microbiota composition make individuals either more or less susceptible to various diseases, including cancer. Specific microbes are associated with cancer etiology and pathogenesis and several mechanisms of how they drive the typical hallmarks of cancer were recently identified. Although most microbes reside in the distal gut, they can influence cancer initiation and progression in distant tissues, as well as modulate the outcomes of established cancer therapies. Here, we describe the mechanisms by which microbes influence carcinogenesis and discuss their current and potential future applications in cancer diagnostics and management.

show abstract

Precision strategies for cancer treatment by modifying the tumor-related bacteria

Cited by 13 publications

References 90 publications

Breaking barriers in cancer treatment: nanobiohybrids empowered by modified bacteria and vesicles

Breaking barriers in cancer treatment: nanobiohybrids empowered by modified bacteria and vesicles

Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Microbiota as the unifying factor behind the hallmarks of cancer

Contact Info

Product

Resources

About