Precision TACE in therapy of primary malignant tumors of liver/hepatocellular carcinoma (HCC)

Bojanovic, A.; Bošnjaković, Petar; Stojanovic, Miroslava M.; Marković, Miroslav; Mrvic, M.; Radić, S; Radovanović, Zoran

doi:10.2298/aci0904143b

Cited by 3 publications

(3 citation statements)

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“…Hepatocellular carcinoma (HCC) is a standout amongst the most well-known threatening tumors. Patients with HCC have poor sensitivity to chemotherapy drugs, and the prognosis among patients is often poor [ 1 , 2 ]. Selective intervention of cell signal transduction is becoming an effective treatment for malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma

et al. 2017

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Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with poor sensitivity to chemotherapy drugs and poor prognosis among patients. In the present study, we downloaded the original data from the Gene Expression Omnibus and compared gene expression profiles of liver cancer cells in patients with HCC with those of colon epithelial cells of healthy controls to identify differentially expressed genes (DEGs). After filtering target microRNAs (miRNA) from core DEGs, we cultured HepG2 cells in vitro, knocked down the miRNA and core mRNAs, and analyzed the effects. We found 228 differentially expressed genes between liver cancer tissue and healthy control tissue. We also integrated the protein-proteininteraction network and module analysis to screen 13 core genes, consisting of 12 up-regulated genes and 1 down-regulated gene. Five core genes were regulated hsa-miR-3613-3p, therefor we hypothesized that hsa-miR-3613-3p was a critical miRNA. After the transfection procedure, we found that changes in hsa-miR-3613-3p were the most obvious. Therefore, we speculated that hsa-miR-3613-3p was a main target miRNA. In addition, we transfected with si (BIRC5, CDK1, NUF2, ZWINT and SPC24), to target genes that can be targeted by miR-3613-3p. Our data shows that BIRC5, NUF2, and SPC24 may be promising liver cancer biomarkers that may not only predict disease occurrence but also potential personalized treatment options.

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Section: Introductionmentioning

confidence: 99%

MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma

et al. 2017

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“…Hepatoma is one of the most frequent malignant tumors in general and the most common liver malignancy because of its high incidence in many populous countries [13,14,15,16]. Significant differences in hepatoma incidence are found across nine geographic regions within the United States [17].…”

Section: Introductionmentioning

confidence: 99%

Spatial Analysis of the Home Addresses of Hospital Patients with Hepatitis B Infection or Hepatoma in Shenzhen, China from 2010 to 2012

Ren

et al. 2014

IJERPH

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Background: Hepatoma associated with hepatitis B infection is a major public health problem in Shenzhen (China) and worldwide. China has the largest number of people infected with the hepatitis B virus (HBV), and many studies have demonstrated that HBV infection is associated with hepatoma development. Shenzhen officials have been attempting to monitor and control these diseases for many years. The methodology and the results of this study may be useful in developing a system to monitor, prevent and control these diseases. Methods: The aim of the study was to analyze HBV infection and hepatoma distribution characteristics and patterns in Shenzhen by combining geographic information system (GIS) technology and spatial analysis. The study used data from patients at the district level from the 2010–2012 population censuses. Results: Only one-third of the patients were female, and 70.7% of all cases were 20–50 years of age. There was no global spatial correlation of the distribution of hepatitis B infections and hepatomas; however, there was a local spatial correlation, and certain sub-districts of the Nanshan district had significant agglomeration effects. Based on incidence density and rate maps, we can conclude that the Shenzhen special zone had a higher incidence density and rate of hepatitis B infections and hepatomas compared with the area outside of the Shenzhen special zone during 2010–2012. Conclusions: This study demonstrated substantial geographic variation in the incidence of hepatitis B infection and hepatoma in Shenzhen. The prediction and control of hepatitis B infections and hepatoma development and interventions for these diseases should focus on disadvantaged areas to reduce disparities. GIS and spatial analysis play an important role in public health risk-reduction programs and may become integral components in the epidemiologic description, analysis and risk assessment of hepatitis B and hepatoma.

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“…The clinical therapy for HCC includes various modalities such as liver resection [ 12 ], liver transplantation [ 13 ], transarterial chemoembolization (TACE) [ 14 ], percutaneous ethanol injection therapy (PEIT) [ 15 ], radiofrequency ablation (RFA) [ 16 ], and chemotherapy including molecular-targeted therapy [ 17 ]. However, the high recurrence rate is a major concern after any treatment [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma

Meguro

Mizuguchi

Kawamoto

et al. 2011

International Journal of Hepatology

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The prognosis of hepatocellular carcinoma (HCC) is affected by tumoral factors and liver functions; therefore it is often difficult to select the appropriate therapeutic methods for HCC. Recently, two global phase III trials showed that sorafenib, which is a tyrosine kinase inhibitor, improved the prognosis of patients with advanced HCC. As a new therapeutic strategy for HCC, sorafenib is expected to expand the indication for HCC in the future. However, it alone is insufficient for the molecular-targeted treatment of HCC because the signaling pathway exists not only in cancer cells but also in normal cells. Recently, cancer stem cells (CSCs) have attracted attention as a novel therapeutic target for HCC. There is now much evidence that stem cell properties such as self-renewal, unlimited proliferation, and differentiation are highly relevant to cancer recurrence and the drug resistance of HCC. In this review, we describe the molecular pathogenesis and the current state and future development of molecular- and CSC-therapeutic targeted agents for HCC, citing various reports.

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Precision TACE in therapy of primary malignant tumors of liver/hepatocellular carcinoma (HCC)

Cited by 3 publications

References 8 publications

MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma

MiR-3613-3p affects cell proliferation and cell cycle in hepatocellular carcinoma

Spatial Analysis of the Home Addresses of Hospital Patients with Hepatitis B Infection or Hepatoma in Shenzhen, China from 2010 to 2012

The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma

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