Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment

Huang, Yue; Liu, Yuan; Shah, Siddharth; Kim, Dongyeop; Simón-Soro, Áurea; Itô, Teiichiro; Hajfathalian, Maryam; Li, Yong; Hsu, Jessica C.; Nieves, Lenitza M.; Alawi, Faizan; Naha, Pratap C.; Cormode, David P.; Koo, Hyun

doi:10.1016/j.biomaterials.2020.120581

Cited by 75 publications

(62 citation statements)

References 53 publications

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“…Zhang et al developed DNA nanozymes for biosensing the presence of dental bacteria [ 158 ]. Similarly, Huang et al presented bifunctional nanozymes that specifically inhibit the pathogenic Streptococcus mutans (pathogen) but not the commensal, Streptococcus oralis using iron oxide nanozymes having oxidase kind activity [ 159 ].…”

Section: Future Of Nanodentistymentioning

confidence: 99%

Nanomaterials in Dentistry: Current Applications and Future Scope

et al. 2022

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Nanotechnology utilizes the mechanics to control the size and morphology of the particles in the required nano range for accomplishing the intended purposes. There was a time when it was predominantly applied only to the fields of matter physics or chemical engineering, but with time, biological scientists recognized its vast benefits and explored the advantages in their respective fields. This extension of nanotechnology in the field of dentistry is termed ‘Nanodentistry.’ It is revolutionizing every aspect of dentistry. It consists of therapeutic and diagnostic tools and supportive aids to maintain oral hygiene with the help of nanomaterials. Research in nanodentistry is evolving holistically but slowly with the advanced finding of symbiotic use of novel polymers, natural polymers, metals, minerals, and drugs. These materials, in association with nanotechnology, further assist in exploring the usage of nano dental adducts in prosthodontic, regeneration, orthodontic, etc. Moreover, drug release cargo abilities of the nano dental adduct provide an extra edge to dentistry over their conventional counterparts. Nano dentistry has expanded to every single branch of dentistry. In the present review, we will present a holistic view of the recent advances in the field of nanodentistry. The later part of the review compiled the ethical and regulatory challenges in the commercialization of the nanodentistry. This review tracks the advancement in nano dentistry in different but important domains of dentistry.

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Section: Future Of Nanodentistymentioning

confidence: 99%

Nanomaterials in Dentistry: Current Applications and Future Scope

et al. 2022

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“…In vivo wound healing 2DMOF/GOx GOx and POD [25] Antibacterial application MIL@GOx-MIL NRs GOx and POD [143] Synergistic bacteria killing l-Arg/GOx@CuBDC GOx and POD [144] Against Inflammation Fe/N-HCNs SOD, POD, CAT, and OXD [72] Bacterial killing MoS 2 /rGO VHS POD, CAT, and OXD [145] Bacterial killing Dex-IONP-GOx GOx and POD [146] Antioxidation ROS scavenging V 2 O 5 @pDA SOD, CAT, and GPx [147] Cytoprotection Mn 3 O 4 nanozyme SOD, CAT, and GPx [148] Preventing oxidative damage Mn 3 O 4 SOD, CAT, and GPx [30] Brain injury triM nanozyme HRP and CAT [136a]…”

Section: Gox and Cat [4b]mentioning

confidence: 99%

“…More importantly, the proposed nanohybrid system was used to treat dental caries in vivo more effectively when compared with the gold standard oral antimicrobial agent (chlorhexidine) without any adverse effects on the gastrointestinal microbiomes and surrounding soft tissue. [ 146 ]…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

107

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Multiple enzyme-driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits of these biological catalytic cascade systems, enormous efforts have been devoted to developing novel cascade catalytic systems to mimic biological cascade catalytic reactions over the past few years. Nanozymes, a class of enzyme mimics, are nanomaterials with enzyme-like catalytic activity. The emergence and development of nanozymes has significantly advanced the development of biomimetic cascade nanoreactors. Currently, biomimetic cascade nanoreactors driven by advanced nanozymes have been widely used and exhibit many advantages such as superior cascade catalytic efficiency and high stability, resulting in significant advancements in biosensing and biomedical applications. The latest advances in understanding the cascade catalytic mechanism of nanozyme-engineered biomimetic cascade catalytic nanoreactors and their progressive applications for biosensing and biomedical applications are comprehensively covered here. First, nanozyme and enzyme/nanozyme-engineered biomimetic cascade catalytic nanoreactors are categorized according to their catalytic mechanism and properties. Then, the biosensing and biomedical applications, including cancer therapy, antibacterial activity, antioxidation, and hyperuricemia therapy of the cascade catalytic systems are covered. The conclusion describes the most important challenges and opportunities remaining in this exciting area of research.

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“…Several reports suggested that nanozymes produced superfluous ROS, mainly attributed to their peroxidase (POD)-like activity, thus acting as a therapeutic for inflammation caused by bacterial infection ( Wang et al, 2017 ; Sun et al, 2020 ; Zhao et al, 2020 ; Huang et al, 2021 ). In the report by Fan et al (2020b) related to the treatment of both bacteria-infected wounds and IBD ( Shi et al, 2018 ), Fe- and N-doped hollow carbon spheres were constructed using a one-pot strategy.…”

Section: Nanozyme-based Treatment Of Inflammationmentioning

confidence: 99%

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Liu

Dai

et al. 2021

Front. Chem.

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Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating different physiological functions in organisms. However, increased amounts of ROS may cause oxidative stress and damage to biomolecules, leading to a variety of diseases including inflammation and even cancer. Therefore, ROS scavenging reagents are needed to maintain healthy levels of ROS. With considerable advances in nanotechnology, nanozymes possess SOD or CAT-like activities with outstanding free radical scavenging activity, facile synthesis conditions, and excellent biocompatibility. Based on these extraordinary properties, nanozymes has been used to modulate the redox homeostasis and relieve the ROS-related injury. This has led to the emergence of nanozyme-based therapies. In the current review, we presented recently developed applications of nanozymes to treat ROS-dependent disorders with an emphasis on inflammatory and brain diseases.

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Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment

Cited by 75 publications

References 53 publications

Nanomaterials in Dentistry: Current Applications and Future Scope

Nanomaterials in Dentistry: Current Applications and Future Scope

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

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