Precisive Incorporation of Multiple Nitrogen Sources into Benzoxazoles via an Iodine-Mediated Electrochemical Four-Component Reaction

Abstract

An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C−N bonds by making use of a simple nitrogen source, such as NH 4 + and formamide. By virtue of this reaction, a variety of benzoxazoles bearing different substituents can be selectively modulated by using different bases. This protocol features a broad substrate scope and good scalability, is transition metal-free and chemical oxidant-free, and exhibits controlled product distribution. Additionally, it also enables a versatile platform for various isotope-labeled ( 15 N and CD 3 ) benzoxazoles.Letter pubs.acs.org/OrgLett