2016
DOI: 10.1016/j.trci.2016.11.006
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Preclinical Alzheimer's disease and longitudinal driving decline

Abstract: IntroductionLinks between preclinical Alzheimer's disease (AD) and driving difficulty onset would support the use of driving performance as an outcome in primary and secondary prevention trials among older adults (OAs). We examined whether AD biomarkers predicted the onset of driving difficulties among OAs.MethodsOne hundred four OAs (65+ years) with normal cognition took part in biomarker measurements, a road test, clinical and psychometric batteries, and self-reported their driving habits.ResultsHigher value… Show more

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Cited by 49 publications
(62 citation statements)
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“…Driving problems arise earlier for participants with preclinical AD [3]. Symptomatic AD (CDR >0) is associated with much faster decline on the NPI-Q than cognitive normality (CDR 0) [7].…”
Section: Discussionmentioning
confidence: 99%
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“…Driving problems arise earlier for participants with preclinical AD [3]. Symptomatic AD (CDR >0) is associated with much faster decline on the NPI-Q than cognitive normality (CDR 0) [7].…”
Section: Discussionmentioning
confidence: 99%
“…In our sample of cognitively normal older adults, presence of neuropsychiatric symptoms interacted with CSF biomarkers to predict a much faster time to receiving a marginal/fail rating on a road test. While preclinical AD alone predicted a faster time to receiving a marginal/fail rating [3], the presence of NPS increases these problems compared to those without preclinical AD or NPS.…”
Section: Discussionmentioning
confidence: 99%
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