Preclinical and clinical effects of Coleus forskohlii, Salacia reticulata and Sesamum indicum modifying pancreatic lipase inhibition in vitro and reducing total body fat

Abstract

Available online A B S T R A C TThe herbal composition of Coleus forskohlii, Salacia reticulata, and Sesamum indicum, standardized for forskolin, mangiferin, and sesamin, respectively, were shown, in vitro, to inhibit pancreatic lipase with differing degrees and dynamics. In the placebo controlled six weeks clinical study the daily intake of 1000 mg C. forskohlii stand-alone standardized for 10% forskolin, showed statistically significant lowering of total body fat vs. baseline and placebo group (p < 0.05).The computerized tomography showed decrease of total body fat and visceral fat in C. forskohlii group in comparison to the baseline. The potential of three herbal extracts preventing dietary fat absorption was emphasized by the in vitro synergy between C. forskohlii and S. reticulata inhibiting pancreatic lipase at higher rate than the fat-blocking activity generated by each component alone. The in vitro addition of S. indicum to the formula was found to synergistically assist inhibition of the pancreatic lipase in a lower dose range, while moderating the pancreatic lipase inhibition in a higher dose range. This dual mechanism of S. indicum was postulated as a safety mechanism preventing any potential side effects resulting from excessive inhibition of pancreatic lipase activity.

A Review of Natural Stimulant and Non‐stimulant Thermogenic Agents

“…Extracts of the seeds of S. indicum have also been shown to modulate lipid metabolism (Biswas et al, 2010;Asgary et al, 2013). As noted earlier, the combination of forskolin with extracts of S. reticulata and S. indicum (FB 3 ) have been shown to work synergistically with respect to prevention of dietary fat absorption decreasing body fat content (Badmaev et al, 2015).…”

Health benefits of sesamin on cardiovascular disease and its associated risk factors

“…PTL hydrolyzes lipids into monoglycerols and free fatty acids in the duodenum, which are then packed into micelle and absorbed into the lymphatic system through lacteals. Blocking of PTL with tetrahydrolipstatin has been utilized in the management of obesity, however has reported several side effects ( Badmaev et al, 2015 ). S. indicum extract (70%) has been found to inhibit the action of PTL by 15% at 1 µg/mL and 17.5% at 100 µg/mL, suggesting that it may possess weight reducing properties ( Badmaev et al, 2015 ).…”

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

“…1), which was dependent not only on the starting material but also on the phenolic fraction examined. Lipases play an important role in the absorption of triacylglycerols [13,44] which is related to body weight management and obesity. The latter one is associated with metabolic syndrome and heart disease.…”