Preclinical Anemia Panel Studies of “Makardhvaja” after Chronic Administration to Male Sprague-Dawley Rats

Ch, Sagor; Roy, ra; Sikder, Md. Mamun; Sarker, Arjyabrata; Uddin, Md. Afaz; Masud, Neshat; Hasan, Md. Rakib; Saha, N; Choudhuri, M. S. K.

doi:10.4172/0974-8369.1000387

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Safety profile studies of drugs or plant extracts allow us to determine the pharmacological effects on various organs and biochemical parameters after chronic drug administration. [14][15][16][17] In this study, the effect of MRS and MSB on glucose homeostasis was evaluated after chronic administration. To determine the average plasma glucose concentration over a prolonged period, Ayurvedic medicinal preparations MRS and MSB were administered chronically to the male Sprague-Dawley rats at a dose of 40 mg/kg and 400 mg/kg, respectively.…”

Section: Resultsmentioning

confidence: 99%

Preclinical Hba1c Level Studies of Makardhwaj Ras and Maha Sankha Bati after Chronic Administration to Male Sprague-Dawley Rats

2024

TJNPR

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Drugs, chemicals, and reagentsIn this study, finished Ayurvedic medicines MRS and MSB were purchased from Sri Kundeswari Aushadhalaya Limited, Chittagong, Bangladesh in 2020 (Ingredients list in Table 1, 2). Experimental animalsEight-week-old male Sprague-Dawley rats bred and maintained in the animal house of the Department of Pharmacy, Jahangirnagar University, were used in this toxicological experiment. These animals were healthy and weighed 50-70 g. The animals were housed in a well ventilated clean experimental animal house under constant environmental and adequate nutritional conditions throughout the experiment. They were fed with rat chow diet prepared according to the formula developed by the Bangladesh Council of Scientific and Industrial Research (BCSIR). Water was provided ab libitum and the animals were kept on a 12-hour day/12-hour night cycle. The animals were handled according to the ethical guidelines and the study protocol was approved by the Biosafety, Biosecurity, and Ethics Committee of Jahangirnagar University (Ethics approval no: BBEC, JU/ M 2018 (5)2),

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Section: Resultsmentioning

confidence: 99%

Preclinical Hba1c Level Studies of Makardhwaj Ras and Maha Sankha Bati after Chronic Administration to Male Sprague-Dawley Rats

2024

TJNPR

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“…[24][25][26][27][28][29] Heavy metals such as mercury in different concentrations is found in all kind of Makaradhwaja formulations and so prolonged use of these medications has a deleterious impact on the liver, kidney, and lipid profile. [30][31][32][33] Previously reported Makardhwaja, which contains sulfur and mercury (24:1), induces considerable elevations in progesterone and luteinizing hormone levels following chronic dosing. 30 In this investigation, rats were administered with SGM to assess their steroidal and gonadotropin hormone profiles, and no significant differences were identified between the treated and control groups, implying that this treatment had no effect on serum circulating steroidal and gonadotropin hormone levels.…”

Section: Discussionmentioning

confidence: 99%

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Kishoara,

Munna,

Mousumi

et al. 2024

Int J Basic Clin Pharmacol

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Background: Saraguna Balijarita Makardhwaja (SGM) is an Ayurvedic preparation used as a traditional antipyretic in the rural population. This research work was designed to get an overview of steroidal and gonadotropin hormone profiles after chronic administration of this drug. Methods: The acute pharmacological test of SGM recorded no death or any signs of effectivity even at the highest dose of 4000 mg/kg body weight. For chronic pharmacological evaluation, sixteen healthy Sprague-Dawley male rats were randomly divided into two groups, one group was a control group and the other was an experimental group. The experimental group was assigned to receive the drug at a dose of 400 mg/kg of body weight orally. After 28 days of treatment, blood samples were collected for biochemical tests. Results: The research showed the following effects on the steroidal and gonadotropin hormone profile. In this study, serum circulating level of dehydroepiandrosterone sulfate (DHEA-S), testosterone level, progesterone, 17-beta-estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured to determine safety profile study of SGM after chronic administration. There were no significant differences in any parameters which is suggesting that SGM has no effect of the steroidal and hormone profile. Conclusions: According to studies, SGM has no harmful effect on the steroid and hormone profiles after chronic treatment. Further studies are needed to establish the safety aspects of SGM.

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“…Some herbs, if not used appropriately, can show toxic effects ( Table 1 ). 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Ayurvedic texts classify herbs according to their safety and potential toxicity. The “Bhavaprakasha Nighantu” and other Ayurvedic pharmacopeias provide information about the toxicity, dosage, and contraindications of various herbs.…”

Section: Toxicological Aspectsmentioning

confidence: 99%

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning

Sikder

2024

Chonnam Med J

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Ayurveda is one of the oldest and most widely practiced traditional medical systems in the world. The ancient knowledge in this traditional medical system has yet to be fully explored. The interaction of rich knowledge from various traditional systems of medicine can open new pathways in the herbal drug discovery process. Apart from other hurdles in discovering plant-based medicines, the lack of knowledge of the differences and similarities between the theoretical doctrines of these systems is the greatest impediment to their convergence. Rasashastra is an Ayurvedic medicine section that deals with formulations that include minerals/metals, particularly Parad (mercury). According to the Ayurvedic Formulary of India, the most widely used heavy metals are mercury, arsenic, and lead. However, contemporary scientists are concerned about the use of heavy metals in Ayurvedic preparation. In this review article, we will discuss Ayurvedic medicine and the toxic effects of heavy metals.

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Preclinical Anemia Panel Studies of “Makardhvaja” after Chronic Administration to Male Sprague-Dawley Rats

Cited by 3 publications

References 17 publications

Preclinical Hba1c Level Studies of Makardhwaj Ras and Maha Sankha Bati after Chronic Administration to Male Sprague-Dawley Rats

Preclinical Hba1c Level Studies of Makardhwaj Ras and Maha Sankha Bati after Chronic Administration to Male Sprague-Dawley Rats

Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats

Ayurvedic Medicine: A Traditional Medical System and Its Heavy Metal Poisoning

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