Preclinical Assessment of Infant Formula

Lönnerdal, Bo

doi:10.1159/000338209

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…There was agreement that the introduction of new or modified infant food products should be preceded by a systematic review of the available evidence, and usually preclinical safety assessment followed by evaluation in clinical trials according to current scientific standards [70,71,72,73]. Consumers and health care professionals expect any new ingredient to be thoroughly tested by scrupulously conducted clinical trials which usually assess growth, monitor adverse events, and are evaluated by the appropriate regulatory body (EFSA for Europe, GRAS status and FDA in the USA) [74,75].…”

Section: Discussionmentioning

confidence: 99%

Quality and Safety Aspects of Infant Nutrition

Koletzko¹,

Shamir

Ashwell

2012

Ann Nutr Metab

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Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition. Unbalanced diets and harmful food components induce particularly high risks for untoward effects in infants because of their rapid growth, high nutrient needs, and their typical dependence on only one or few foods during the first months of life. The concepts, standards and practices that relate to infant food quality and safety were discussed at a scientific workshop organized by the Child Health Foundation and the Early Nutrition Academy jointly with the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, and a summary is provided here. The participants reviewed past and current issues on quality and safety, the role of different stakeholders, and recommendations to avert future issues. It was concluded that a high level of quality and safety is currently achieved, but this is no reason for complacency. The food industry carries the primary responsibility for the safety and suitability of their products, including the quality of composition, raw materials and production processes. Introduction of new or modified products should be preceded by a thorough science based review of suitability and safety by an independent authority. Food safety events should be managed on an international basis. Global collaboration of food producers, food-safety authorities, paediatricians and scientists is needed to efficiently exchange information and to best protect public health.

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Section: Discussionmentioning

confidence: 99%

Quality and Safety Aspects of Infant Nutrition

Koletzko¹,

Shamir

Ashwell

2012

Ann Nutr Metab

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“…Considering formula commonly, it is important to discover and apply novel methods of analysis, such as 'omics', and evaluation of clinical outcomes [37].…”

Section: Nutrimetabolomicsmentioning

confidence: 99%

Metabolomics in the developing infant

Fanos

Antonucci²,

Atzori

2013

Current Opinion in Pediatrics

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“…Infant's formulas are the predominant source of nutrition for many infants and are fed during a sensitive period of development, having probably short-and long-term consequences for infant health [1]. In terms of food safety, infants and children are considered to be a part of the high-risk group of individuals, as their immune systems may have not yet be fully developed [2].…”

Section: Introductionmentioning

confidence: 99%

Microbiological Assessment of Some Powdered Infant Formulas: From Quality to Antibiotic Resistance Evaluation

Toscano¹

2013

J Food Process Technol

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Living bacteria are daily used for human consumption as food supplements, also in infant formulas.The amount of ingested viable cells seems to be able to influence the probiotic effectiveness; so it is essential that products available on the market are correctly labelled and that the viability and identity of each strain is ensured. For this purpose, an analysis was conducted on 8 commercial infant formulas to evaluate their stability until the recommended consumption date, the bacterial load and the antibiotic susceptibility of strains used in aforementioned products. Conventional cultural methods were used to isolate and enumerate microorganisms, while their identification was performed by mean of Pyrosequencing. Finally, Minimum Inhibitory Concentrations (MIC) for erythromycin, penicillin, ciprofloxacin and tetracycline were determined using E test. Most of the tested infant formulas were correctly labelled and the number of viable cells remained stable until the recommended consumption date; however, one product did not contain viable cells of one bacterial species reported in the label. Moreover, all products contained strains showing resistance to at least one antibiotic; resistance to tetracycline and ciprofloxacin was rather common among the tested strains. In conclusion, most of the products analysed in this study were correctly labelled and contained a sufficient amount of bacteria. Although, the antibiotic resistance found in all probiotic strains underlined the need for further investigations about the real safety of probiotic strains used as food supplements.

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Preclinical Assessment of Infant Formula

Cited by 34 publications

References 27 publications

Quality and Safety Aspects of Infant Nutrition

Quality and Safety Aspects of Infant Nutrition

Metabolomics in the developing infant

Microbiological Assessment of Some Powdered Infant Formulas: From Quality to Antibiotic Resistance Evaluation

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