Preclinical assessment of stem of Nicotiana tabacum on excision wound model

Sharma, Yash; Kaur, Amritpal; Bhardwaj, Rohit; Srivastava, Nidhi; Lal, Manisha; Madan, Swati; Bala, Kumud

doi:10.1016/j.bioorg.2021.104731

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…All the phytochemicals were found in all the five plant species. Some earlier researchers have reported results similar to the current study, such as [24] reported that the aqueous extract of N. tabacum leaves tested positive for alkaloids, tannins, flavonoids, steroids, car-diac glycosides, essential oils, resins, and polypeptides. [25] stated that tobacco leaves contain nicotine, as we know that nicotine is an alkaloid which is the most biologically active component of tobacco.…”

Section: Discussionsupporting

confidence: 89%

Biorational Control of Callosobruchus maculatus (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts

Akbar

Khan

Faheem

et al. 2022

BioMed Research International

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Globally, around 2000 plant species are used against pest control. The utilization of botanicals is considered the most economic and biodegradable methods for the control of stored grains pests. Therefore, the current study was carried out to investigate the repellency potential of five botanicals against Callosbruchus maculatus F. in Haripur, Pakistan. The concentrations of Azadirachta indica L., Nicotiana tabacum L., Melia azedarach L., Nicotiana rustica L., and Thuja orientalis L. were, i.e., 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0% in four replicates to establish contact effects. The data were recorded after 1, 2, 3, 6, 24, 48, 72, and 96 hours. The repellency effect of these plant species against C. maculatus were increased in both the time- and dose-dependent manner, and highest effect was observed at 72 h. In addition, the repellency effect was 91% for A. indica (class: V), 86% M. azedarach, 82%, N. tabacum (class: V), 79% N. rustica (class: IV), and 75% T. orientalis (class: IV) at 3% concentration against C. maculatus. Furthermore, following 96 hours’ exposure to treatment the sensitivity response of insects decreases as the time interval increases, i.e., 86% A. indica (class: V) was followed by 71% M. azedarach (class: IV), 65% N. tabacum (class: IV), 61% N. rustica (class: IV), and T. orientalis 57% (class: III) repellency at highest concentration of 3%. The current study concluded that A. indica and M. azedarach can be incorporated for the management of C. maculatus and these plant species might be helpful in the productions of new biopesticides.

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Section: Discussionsupporting

confidence: 89%

Biorational Control of Callosobruchus maculatus (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts

Akbar

Khan

Faheem

et al. 2022

BioMed Research International

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“…The extractor was then allowed to heat to reflux for 16 h at 70 °C. Extracts were filtered twice through a Whatman No.1 paper filter and concentrated to the dry mass with the aid of rotary evaporator 49 .…”

Section: Methodsmentioning

confidence: 99%

“…Absorbance of the mixture was measured at 725 nm. Final results were represented as quercetin equivalents (mg QE)/g of extract and tannic acid equivalents (mg TA)/g of extract, respectively 44 , 49 , 51 . All the concentrations were calculated using a standard calibration plot.…”

Section: Methodsmentioning

confidence: 99%

“…A calibration curve was prepared using FeSO4 × 7H2O. FRAP values were expressed as mM Fe (II)/g dry weight of extract 49 , 53 , 54 .…”

Section: Methodsmentioning

confidence: 99%

“…To plot the standard calibration curves, standard stock solutions of rutin, tannic acid, and piperine were produced in methanol at various concentrations (5–100 µg/mL). The results were expressed as milligrams of each compound per g of dry weight (DW) of the extract 49 .…”

Section: Methodsmentioning

confidence: 99%

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In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Kaur

Sharma

Kumar³

et al. 2022

Sci Rep

Self Cite

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Abrus precatorius is a tropical medicinal plant with multiple medicinal benefits whose seeds have not yet been studied against cervical cancer. Herein, we have assessed the antioxidant and antiproliferative properties of seed extracts (ethyl acetate and 70% ethanol) prepared from Soxhlet and Maceration extraction methods against Hep2C and HeLa Cells. We observed that the APE (Sox) extract had a significantly higher total flavonoid content, APA (Mac) extract had a high total phenolic content, and APA (Sox) extract had a high total tannin content. Further, HPLC analysis of extracts revealed the presence of tannic acid and rutin. Moreover, APA (Sox) exhibited the highest free radical scavenging activity. APE (Mac) had the best antiproliferative activity against Hep2C cells, while APA (Sox) had the best antiproliferative activity against HeLa cells. In Hep2C cells, APE (Mac) extract revealed the highest SOD, catalase activity, GSH content, and the lowest MDA content, whereas APA (Mac) extract demonstrated the highest GST activity. In HeLa cells, APA (Sox) extract showed the highest SOD, GST activity, GSH content, and the least MDA content, whereas APA (Mac) extract showed the highest catalase activity. Lastly, docking results suggested maximum binding affinity of tannic acid with HER2 and GCR receptors. This study provides evidence that A. precatorius seed extracts possess promising bioactive compounds with probable anticancer and antioxidant properties against cervical cancer for restricting tumor growth.

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Medicinal plants used for cutaneous wound healing in Uganda; ethnomedicinal reports and pharmacological evidences

Gang,

Okello,

Kang

2024

Heliyon

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Preclinical assessment of stem of Nicotiana tabacum on excision wound model

Cited by 10 publications

References 22 publications

Biorational Control of Callosobruchus maculatus (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts

Biorational Control of Callosobruchus maculatus (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts

In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma

Medicinal plants used for cutaneous wound healing in Uganda; ethnomedicinal reports and pharmacological evidences

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