Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153

Abstract

This work is devoted to studying the in vivo antitumor efficacy of the new injection radiopharmaceutical based on thermoresponsive polymer and β − -emitting radionuclide samarium-153 ( 153 Sm-KARP-CheM).The study of in vivo antitumor efficacy was performed using mice F1 and C57Bl/6 with transplanted subcutaneously sarcoma S37 and melanoma B16, respectively. The animals received single intratumoral bolus injections of 37 MBq (1 mCi), or 18.5 MBq (0.5 mCi) of 153 Sm-KARP-CheM, or saline in a volume 0.1 ml. The efficacy of antitumor treatment was evaluated using tumor growth inhibition index (TGI, %) and increase of average life span (ILS, %).The most meaningful therapeutic efficacy after intratumoral injection of 153 Sm-KARP-