Preclinical Evaluation of Antiurolithiatic Activity of <i>Viburnum opulus</i> L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

İlhan, Mert; Ergene, Burçin; Süntar, İpek; Özbilgin, Serkan; Saltan, Gülçin; Demırel, Mürşide Ayşe; Keleş, Hikmet; Altun, Levent; Akkol, Esra Küpeli

doi:10.1155/2014/578103

Cited by 41 publications

(32 citation statements)

References 22 publications

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“…In line with our findings, a report of an experimental model has shown the beneficial effect of V. opulus treatment on the levels of total thiols and glutathione [30] . MDA elevation shows increased lipid peroxidation due to the interaction between lipid components of cellular membranes and ROS [31] .…”

Section: Discussionsupporting

confidence: 93%

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Eken¹,

Yücel²,

Boşgelmez³

et al. 2017

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the protective effect of Viburnum opulus L. fruit extract against ischemia/reperfusion (I/R)-induced oxidative stress during the lung transplantation. For this purpose, 30 female rats were firstly randomized to form of donor and recipients. After then, the rats were divided into three groups named as control, I/R, and V. opulus + I/R. Experimental rats were subjected to lung transplantation with ischemia followed by 2 h of reperfusion. Transplantation-related lung injury was evaluated by multiple parameters. A significant decrease was observed in the enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), and the levels of glutathione and total antioxidant status (TAS), whereas the levels of malondialdehyde (MDA), total oxidant status (TOS), and protein carbonyl were significantly increased in lung tissue samples of I/R group in comparison to the control group. However, treatment with V. opulus fruit extract resulted in significant reduction of MDA and protein carbonyl levels and increment of the antioxidant system. In conclusion, V. opulus fruit extract showed protective effects against I/R-induced oxidative stress during lung transplantation probably by the radical scavenging and antioxidant activity. Therefore, this fruit extract can be efficient in the prevention of I/R-related lung toxicity. Keywords: Oxidative Stress, Transplantation, Ischemia/Reperfusion, Antioxidant Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Strese Karşı Viburnum opulus L. Meyve Ekstresinin Koruyucu Etkisinin Araştırılması ÖzetBu çalışma, akciğer transplantasyonu sırasında iskemi/reperfüzyonun indüklediği oksidatif hasara karşı Viburnum opulus L. meyve ekstresinin koruyucu etkisini araştırmak amacıyla yapılmıştır. Bu amaçla, ilk olarak donör ve alıcı oluşturmak için 30 dişi rat rastgele seçildi. Daha sonra, ratlar kontrol, I/R ve V. opulus + I/R olarak adlandırılan üç gruba ayrıldı. Deneysel ratlara iskeminin ardından 2 saat reperfüzyon ile akciğer transplantasyonu yapıldı. Transplantasyon ile ilişkili akciğer hasarı, farklı parametrelerle incelendi. Kontrol grubu ile karşılaştırıldığında I/R grubunun akciğer doku örneklerinde süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx) ve katalaz (CAT) enzim aktiviteleri, glutatyon ve total antioksidan durum (TAS) düzeylerinde önemli bir azalış, malondialdehit (MDA), total oksidan durum (TOS) ve protein karbonil düzeylerinde anlamlı artış belirlendi. Bununla birlikte, V. opulus meyve ekstresi ile uygulama sonrası MDA ve protein karbonil düzeylerinde önemli azalma ve antioksidan sistemde artma saptanmıştır. Sonuç olarak, akciğer transplantasyonu sırasında I/R'nin indüklediği oksidatif strese karşı V. opulus meyve ekstresinin muhtemel radikal temizleme ve antioksidan aktivitesi ile koruyucu etkilerinin olduğunu göstermiştir. Bu nedenle, bu meyve ekstresi I/R ilişkili akciğer hasarının önlenmesinde etkili olabilir.

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Section: Discussionsupporting

confidence: 93%

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Eken¹,

Yücel²,

Boşgelmez³

et al. 2017

Kafkas Univ Vet Fak Derg

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“…Phenolic compounds may prevent the lipid peroxidation-induced renal damage caused by CaOx crystal deposition in the kidney. It was also reported that hypoglccemic, antihyperlipidemic, anti-inflammatory, and antioxidant activities of chlorogenic acid may improve the renal function in diabetic nephropathy [42]. Recent studies have shown that the flavonoids could effectively inhibit the formation of CaOx stones in vitro and in vivo, correlating with their diuretic, antioxidant, anti-inflammatory, antibacterial properties and other protective effects [43].…”

Section: Discussionmentioning

confidence: 98%

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

KELEŞ¹,

Şen²,

Ertaş³

et al. 2020

jrp

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Nephrolithiasis is common urological problem and stone formation has multiple underlying pathogenetic factors. We investigated the possible preventive and therapeutic effects of Urtica dioica ethanol extract (UD) on ethylene glycol-induced nephrolithiasis model in rats. Sprague-Dawley rats were divided into four groups (n = 10). The control group was given normal drinking water for 8 weeks and was administered vehicle by gastric gavage. Stone formation was induced by adding 0.75% ethylene glycol (EG) to their drinking water. UD (700 mg/kg) was given orally for 8 weeks to the preventive group and for last 4 weeks to the treatment group, respectively. At the end of the experiment, urine, blood samples and kidney tissues were obtained. In 24-hour urine samples, calcium and citrate levels were decreased and oxalate levels were increased in EG group whereas UD treatment groups reversed these parameters back to control levels. In addition, serum levels of creatinine and urea were increased in EG group, while UD significantly reduced these parameters. Malondialdehyde, 8-hydroxydeoxyguanosine and tumor necrosis alpha levels, and caspase-3 and N-acetyl-β-glucosaminidase activities were elevated in EG group and showed a decrease in UD treated groups. Glutathione level was decreased in EG group, whereas it was increased in UD preventive group. Histological examination showed an improvement in UD treated groups. Our results suggest that UD is effective both in prevention and treatment for kidney stones. The mechanism underlying this effect may be the antioxidant effect of UD and the effect on the concentration of stone-forming components in the urine.

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“…[16] It has been shown in preclinical studies that this plant, which grows widely in Central Anatolia, has antioxidant, antiurolithiatic, antispasmodic, anti-inflammatory, and antinociceptive effects. [17,18] The aim of the present study was to analyze the efficacy of V. opulus, an alternative herbal treatment method, in distal ureteral stones <10 mm. To the best of our knowledge, this is the first clinical trial evaluating the efficacy of V. opulus in the treatment of ureteral stones.…”

Section: Introductionmentioning

confidence: 99%

The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones

Kızılay

Ülker²,

Çelik³

et al. 2019

Turkish Journal of Urology

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Objective: Medical expulsive therapy is an important non-invasive treatment modality that facilitates the passage of ureteral stones. The aim of the present study was to evaluate the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm. Material and methods: Data of 103 patients were retrospectively analyzed. Patients were divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50). Comparisons of stone expulsion rates and the elapsed time until the expulsion between the groups were determined as primary outcome measures. The comparison of the need for additional treatment [ureteroscopy (URS) or extracorporeal shock wave lithotripsy (ESWL)], the need for emergency admission, analgesic requirement, and the complication rates in additional treatment were determined as secondary outcome measures. Results: The mean age of the patients was 45.8±14.5 years. The rate of stone expulsion was significantly higher (82% vs. 66%, p= 0.026), and elapsed time to stone expulsion was significantly shorter (9±1.8 vs. 14±2.3 day, p= 0.018) in the V. opulus group. The need for additional treatment (URS and ESWL) and analgesic requirement was less in the V. opulus group (9.4% vs. 20%, p= 0.038 and 24.5% vs. 44%, p= 0.042, respectively). Conclusion: V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results.

show abstract

Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

Cited by 41 publications

References 22 publications

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

Ratlarda Akciğer Transplantasyonda Iskemi/Reperfüzyonun İndüklediği Oksidatif Hasara Karşı Viburnum opulus Meyve Ekstresinin Koruyucu Etkilerinin Araştırılması

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones

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