Preclinical evaluation of holmium‐166 labeled anti‐VEGF‐A(Bevacizumab)

Khorami-Moghadam, Alireza; Bolouri, Bahram; Jalilian, Amir Reza; Bahrami-Samani, Ali; Mazidi, Seyed Mohammad; Alirezapour, Behrouz

doi:10.1002/jlcr.3044

Cited by 4 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Khorami-Moghada et al provided a study on a colon cancer model in mice, labelling 166 Ho to the VEGF-A antibody bevacizumab. The biodistribution results show high uptake in the liver, blood, kidneys and in the tumours (Khorami-Moghadam et al 2013). Unfortunately, the article is not very clear in its material and methods and therefore it is difficult to estimate the real value.…”

Section: Intravenous Applicationsmentioning

confidence: 99%

The various therapeutic applications of the medical isotope holmium-166: a narrative review

Klaassen¹,

Arntz²,

Arranja

et al. 2019

EJNMMI radiopharm. chem.

View full text Add to dashboard Cite

Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for production of nuclear reactor derived holmium-166. Several compounds labelled with holmium-166 are now used in patients, such Ho 166 -labelled microspheres for liver malignancies, Ho 166 -labelled chitosan for hepatocellular carcinoma (HCC) and [ 166 Ho]Ho DOTMP for bone metastases. The outcomes in patients are very promising, making this isotope more and more interesting for applications in interventional oncology. Both drugs as well as medical devices labelled with radioactive holmium are used for internal radiotherapy. One of the treatment possibilities is direct intratumoural treatment, in which the radioactive compound is injected with a needle directly into the tumour. Numerous other applications have been developed, like patches for treatment of skin cancer and holmium labelled antibodies and peptides. The second major application that is currently clinically applied is selective internal radiation therapy (SIRT, also called radioembolization), a novel treatment option for liver malignancies. This review discusses medical drugs and medical devices based on the therapeutic radionuclide holmium-166.

show abstract

Section: Intravenous Applicationsmentioning

confidence: 99%