Preclinical Evaluation of Safety of Fucoidan Extracts From <i>Undaria pinnatifida</i> and <i>Fucus vesiculosus</i> for Use in Cancer Treatment

Bovet, Luc; Samer, Caroline Flora; Daali, Youssef

doi:10.1177/1534735419876325

Cited by 5 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, fucoidan does not support tumor growth, and its immunomodulatory effect may inhibit tumor growth; however, this evidence needs to be validated in future clinical trials. Future research is needed to corroborate the findings of fucoidans in combination with chemotherapy [188,189].…”

Section: Challenges and Future Prospectsmentioning

confidence: 98%

Biological and Pharmacological Activity of Plant Natural Compounds III

2023

View full text Add to dashboard Cite

Cover image courtesy of Raffaele Pezzani © 2023 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND.

show abstract

Section: Challenges and Future Prospectsmentioning

confidence: 98%

Biological and Pharmacological Activity of Plant Natural Compounds III

2023

View full text Add to dashboard Cite

show abstract

“…Owing to the characteristics of high incidence and high mortality of tumor, the prevention and treatment of tumor has become a global research trend. Fucoidan can exert anti-tumor effects mainly by inducing apoptosis [16,17], arresting cell cycle [18], inhibiting cell migration [18][19][20], and so on. cells, and the effect of inducing apoptosis of HT-29 cells was the most significant.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Induces Apoptosis of HT-29 Cells via the Activation of DR4 and Mitochondrial Pathway

Bai

Wang

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Fucoidan has a variety of pharmacological activities, but the understanding of the mechanism of fucoidan-induced apoptosis of colorectal cancer cells remains limited. The results of the present study demonstrated that the JNK signaling pathway is involved in the activation of apoptosis in colorectal cancer-derived HT-29 cells, and fucoidan induces apoptosis by activation of the DR4 at the transcriptional and protein levels. The survival rate of HT-29 cells was approximately 40% in the presence of 800 μg/mL of fucoidan, but was increased to 70% after DR4 was silenced by siRNA. Additionally, fucoidan has been shown to reduce the mitochondrial membrane potential and destroy the integrity of mitochondrial membrane. In the presence of an inhibitor of cytochrome C inhibitor and DR4 siRNA or the presence of cytochrome C inhibitor only, the cell survival rate was significantly higher than when cells were treated with DR4 siRNA only. These data indicate that both the DR4 and the mitochondrial pathways contribute to fucoidan-induced apoptosis of HT-29 cells, and the extrinsic pathway is upstream of the intrinsic pathway. In conclusion, the current work identified the mechanism of fucoidan-induced apoptosis and provided a novel theoretical basis for the future development of clinical applications of fucoidan as a drug.

show abstract