“…Regarding bone regeneration, previous preclinical and clinical studies revealed that CO 3 Ap granules significantly enhanced bone regeneration like alveolar ridge preservation and guided bone regeneration [ [22] , [23] , [24] , [25] , [26] ]. However, there are limited numbers of preclinical and clinical research to evaluate the efficacy of CO 3 Ap granules for periodontal regeneration [ [27] , [28] , [29] ]. Surprisingly, there are no clinical studies assessing the efficacy of single use of CO 3 Ap granules for periodontal tissue regeneration.…”