2023
DOI: 10.1016/j.reth.2023.01.002
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Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model

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Cited by 7 publications
(6 citation statements)
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“…Severe adverse events were not observed thorough out the study except slight postoperative pain, rednee, and swelling at the test sites. Our findings matched the previous preclinical and clinical studies assessing the safety of CO 3 Ap granules in periodontal regenerative therapy [ [27] , [28] , [29] ].…”
Section: Discussionsupporting
confidence: 90%
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“…Severe adverse events were not observed thorough out the study except slight postoperative pain, rednee, and swelling at the test sites. Our findings matched the previous preclinical and clinical studies assessing the safety of CO 3 Ap granules in periodontal regenerative therapy [ [27] , [28] , [29] ].…”
Section: Discussionsupporting
confidence: 90%
“…Regarding bone regeneration, previous preclinical and clinical studies revealed that CO 3 Ap granules significantly enhanced bone regeneration like alveolar ridge preservation and guided bone regeneration [ [22] , [23] , [24] , [25] , [26] ]. However, there are limited numbers of preclinical and clinical research to evaluate the efficacy of CO 3 Ap granules for periodontal regeneration [ [27] , [28] , [29] ]. Surprisingly, there are no clinical studies assessing the efficacy of single use of CO 3 Ap granules for periodontal tissue regeneration.…”
Section: Introductionmentioning
confidence: 99%
“…Six healthy beagle dogs (1‐year‐old males) were included in the sample. All surgical procedures were conducted as previously described with slight modifications 27 …”
Section: Methodsmentioning
confidence: 99%
“…To adhere to the 3R principle and minimize the overall number of animals, the right sides of the mandibles were also applied to other experimentations. After healing, one‐wall intrabony defects (5 mm in height and 4 mm in width) were made on the distal surfaces of the second premolars and the mesial of the fourth premolars in the mandible according to previous studies 27–29 . In this study, all surgical procedures were performed by a single periodontal specialist (M.O.).…”
Section: Methodsmentioning
confidence: 99%
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