Preclinical Evaluation of the <i>Enceliacanescens Lam</i> Extract: Medicinal Properties useful for Cancer Treatment

Abstract

Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

Protection of Erythrocytes against Lipoperoxidation and Antiinflammatory Effects of Ethanolic Extract of Encelia canescens Lam Leaves in Mice

“…These metabolites have also been identified in Chile by Cayún et al (2015), except for alkaloids; it seems that the climate and altitudinal floors in Peru are favorable for the development of these secondary metabolites. 13,28 According to the reviewed literature, flavonoids, tannins, coumarins, steroids and/or Legend: Presence (+), absence (-). triterpenes are metabolites that have demonstrated anti-inflammatory and antioxidant effects, contributing to the prevention of chronic diseases of higher prevalence.…”

“…5 The four main types of NCDs are cardiovascular, cancer, lung, and diabetes 6 ; in such a way that one of the main causes of these diseases is oxidative stress 7 , a process that shows an imbalance between oxidants and antioxidants and that is the cause of cellular damage. [7][8][9] Peru is considered an area of high plant richness and mainly of the Asteraceae, with more than 1613 species 10 within them we have the species Encelia canescens Lam (E. canescens) known as "coronilla del fraile" or "hierba lingo" that is empirically used for its analgesic 11 , galactophore properties, menstruation regulation 12 , cancer treatment 13 and viral and bacterial diseases, against urine retention. 11 This species has triterpenoids 14 , steroids, flavonoids, coumarins, and tannins 13 , being flavonoids, metabolites with potential antioxidant and anti-inflammatory activity 15,16 , but triterpenoids has same anti-inflammatory activities.…”

“…[7][8][9] Peru is considered an area of high plant richness and mainly of the Asteraceae, with more than 1613 species 10 within them we have the species Encelia canescens Lam (E. canescens) known as "coronilla del fraile" or "hierba lingo" that is empirically used for its analgesic 11 , galactophore properties, menstruation regulation 12 , cancer treatment 13 and viral and bacterial diseases, against urine retention. 11 This species has triterpenoids 14 , steroids, flavonoids, coumarins, and tannins 13 , being flavonoids, metabolites with potential antioxidant and anti-inflammatory activity 15,16 , but triterpenoids has same anti-inflammatory activities. 17,18 Antioxidant capacity can be measured in lipoperoxidation processes and also by means of oxidative stress markers 6 ; since lipid oxidation has been shown to be associated with damage at level of the cell membrane, this leads to apoptosis in a wide variety of cells.…”