Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies

Abstract

Objective: This study evaluated the reno-protective effects of quercetin in animal models of acute kidney injury (AKI).Methods: We conducted a systematic search of literature published before April 2023 in PubMed, Web of Science, and EMBASE databases. Methodological quality was assessed by SYRCLE’s RoB tool. Funnel plot, Egger’s test, and Begg’s test were used to determine publication bias.Results: A total of 19 studies with 288 animals were included in this meta-analysis. The methodology quality scores of the included studies ranged from 4 to 7. The results indicated that quercetin reduced blood urea nitrogen (SMD = −4.78; 95% CI: 6.45, −3.12; p < 0.01; I2 = 84%) and serum creatinine (SMD: 2.73, 95% CI: 3.66, −1.80; p < 0.01; I2 = 80%) in AKI models. The result of sensitivity analysis was stable, while the results of funnel plot indicated asymmetric. In addition, we further analyzed inflammatory cytokines, oxidative stress levels, and kidney injury scores, and found that quercetin treatment had antioxidant and anti-inflammatory effects and improved kidney injury scores in animal models of AKI.Conclusion: Quercetin exhibited a promising reno-protective effect in AKI animal models.Systematic Review Registration: PROSPERO (CRD42023433333).

Ameliorative action of “daitongxiao” against hyperuricemia includes the “uric acid transporter group”

“…The upregulation of XOD activity accelerates the production of UA, enhancing the levels of UA ( Stamp et al, 2021 ). Cre and BUN are sensitive indicators of renal function ( Nakada et al, 2023 ; Zeng et al, 2023 ). To investigate the effects of DTX on XOD activity, UA level, and renal function in the HUA quail model, the serum levels of UA, XOD, Cre, and BUN were examined on days 14, 21, 28, and 35.…”

“…SU can be used to evaluate the degree of pathogenesis of HUA. Cre and BUN are sensitive indicators for assessing renal function ( Nakada et al, 2023 ; Zeng et al, 2023 ). In this study, compared with those in the control group, the urinary UA levels were significantly decreased and the Cre levels were significantly increased in the HUA model group ( p < 0.05 or p < 0.01) ( Figures 3D–H ).…”