Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies

Xiao, Feng; Bu, Fan; Huang, L. B. F.; Xu, Wenzhong; Wang, Wenbin; Wu, Qiulian

doi:10.1016/j.ejphar.2022.174868

Cited by 16 publications

(6 citation statements)

References 67 publications

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“…On the other side, there was a significant decrease in the level of MDA and significant increase in the level of SOD and GSH when diabetic rats treated with quercetin. Quercetin has antioxidant potential and these findings agree with Feng et al ( 2022 ) who observed the antioxidant effects of quercetin in diabetic nephropathy.…”

Section: Discussionsupporting

confidence: 91%

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

El-Shaer

Hegazy

Muhammad

2023

Environ Sci Pollut Res

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Diabetes mellitus (DM) is a dysmetabolic disease characterized by chronic hyperglycemia. In the developed countries, DM is the commonest life style disease that affects both old and young age. Nod-like receptor protein-3 (NLRP3)-mediated pyroptosis may in fact aid in the development of diabetic complications. Quercetin is a natural flavonoid, can be present in natural foods and plants. Many studies have reported the antioxidant role of quercetin on different tissues, but its effects on NLRP3-mediated pyroptosis in diabetic lung are unclear. The current study aimed to assess quercetin’s protective effects on lung function, oxidative stress, and NLRP3-mediated pyroptosis in Wister rats exposed to streptozotocin (STZ)-induced DM. Forty male Wister rats were randomly allocated into four equal groups. The groups of rats were as follows: group 1 (G1) was kept under normal control conditions; G2 was injected I/P quercetin at a dose of 30 mg/kg b.wt., daily for 30 days; G3 and G4 were injected with a single dose of streptozotocin (STZ) 50 mg/kg b.wt. I/P to induce DM. After 72-h post diabetes induction, the rats of G4 were treated with quercetin as a manner in the second group. The results showed that quercetin ameliorates the pulmonary dysfunctions caused by DM through restoring the levels of glucose, insulin, and arterial blood gases, as well as the oxidative markers. Also, NLRP3-pyroptosis-mediated IL1β was inhibited. Quercetin also reduces the effect of DM on the lung by decreasing the pathological changes in the lung. In conclusion, NLRP3 inflammasome-induced pyroptosis may aggravate lung injury in diabetic rats. Quercetin has the potential to ameliorate diabetes induced pulmonary dysfunction by targeting NLRP3.

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Section: Discussionsupporting

confidence: 91%

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

El-Shaer

Hegazy

Muhammad

2023

Environ Sci Pollut Res

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“…Through comprehensive literature review identified high heterogeneity as a common issue in experimental meta-analyses. The conduct of experiments may contribute to selection bias, given that positive results are more likely to be reported (Feng et al, 2022). These factors limit the generalizability of our results to clinical settings.…”

Section: Limitationsmentioning

confidence: 97%

A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis

Huang,

Guo,

et al. 2024

Front. Pharmacol.

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ObjectiveThis meta-analysis aimed to determine the efficacy of curcumin in preventing liver fibrosis in animal models.MethodsA systematic search was conducted on studies published from establishment to November 2023 in PubMed, Web of Science, Embase, Cochrane Library, and other databases. The methodological quality was assessed using Sycle’s RoB tool. An analysis of sensitivity and subgroups were performed when high heterogeneity was observed. A funnel plot was used to assess publication bias.ResultsThis meta-analysis included 24 studies involving 440 animals with methodological quality scores ranging from 4 to 6. The results demonstrated that curcumin treatment significantly improved Aspartate aminotransferase (AST) [standard mean difference (SMD) = -3.90, 95% confidence interval (CI) (−4.96, −2.83), p < 0.01, I2 = 85.9%], Alanine aminotransferase (ALT)[SMD = − 4.40, 95% CI (−5.40, −3.40), p < 0.01, I2 = 81.2%]. Sensitivity analysis of AST and ALT confirmed the stability and reliability of the results obtained. However, the funnel plot exhibited asymmetry. Subgroup analysis based on species and animal models revealed statistically significant differences among subgroups. Furthermore, curcumin therapy improved fibrosis degree, oxidative stress level, inflammation level, and liver synthesis function in animal models of liver fibrosis.ConclusionCurcumin intervention not only mitigates liver fibrosis but also enhances liver function, while concurrently modulating inflammatory responses and antioxidant capacity in animal models. This result provided a strong basis for further large-scale animal studies as well as clinical trials in humans in the future.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42024502671.

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“…The treatment of quercetin considerably reduced oxidative stress (lowered malondialdehyde while raising superoxide dismutase and catalase activity) and enhanced a number of renal function markers. By lowering levels of interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-a), it also demonstrated antiinflammatory effects (Feng et al, 2022). Mesangial index, Scr, BUN, proteinuria, BG, and other indicators were decreased by quercetin, whereas HDL-C, SOD, GSH, and other markers were increased.…”

Section: Quercetinmentioning

confidence: 99%

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

Hashim,

Badruddeen,

Akhtar

et al. 2023

J. Phytonanotech. Pharmaceut. Sci.

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Diabetic nephropathy is a debilitating complication of diabetes mellitus characterized by progressive kidney damage. This review provides a comprehensive overview of the molecular pathways underlying its pathogenesis and explores the protective mechanisms offered by various phytobioactives. The pathogenetic mechanisms of diabetic nephropathy are multifaceted, encompassing the activation of key pathways such as the rennin angiotensin-aldosterone system (RAAS), the polyol pathway, protein kinase C (PKC) pathway, hexosamine pathway, and the formation of advanced glycation end products (AGEs). Understanding these pathways is crucial for developing effective therapeutic strategies to combat diabetic nephropathy. In parallel, this review sheds light on the role of phytobioactives, including alkaloids, flavonoids, tannins, and stilbenes, in mitigating the progression of diabetic nephropathy. These natural compounds exhibit a spectrum of protective properties, including antioxidative and anti-inflammatory effects. Their ability to modulate the molecular pathways implicated in diabetic nephropathy offers promising avenues for novel therapeutic interventions. This review of the pathogenetic mechanisms and the protective potential of phytobioactives underscore the importance of considering natural compounds as adjunctive therapies in managing diabetic nephropathy, potentially improving patient outcomes and quality of life.

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Preclinical evidence of the effect of quercetin on diabetic nephropathy: A meta-analysis of animal studies

Cited by 16 publications

References 67 publications

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis

Diabetic nephropathy: An outline on molecular mechanism and protective pathways of phytoconstituents

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