2020
DOI: 10.1038/s41598-020-63634-z
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Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer

Abstract: Despite improvements in surgery and medical treatments, epithelial ovarian cancer (EOC) remains the most lethal gynaecological malignancy. Aim of this study is to investigate the preclinical immunotherapy activity of cytokine-induced killer lymphocytes (CIK) against epithelial ovarian cancers, focusing on platinum-resistant settings. We generated CIK ex vivo starting from human peripheral blood samples (PBMCs) collected from EOC patients. Their antitumor activity was tested in vitro and in vivo against platinu… Show more

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Cited by 11 publications
(5 citation statements)
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“…The great peculiarity of such effector cells is the major histocompatibility complex (MHC)-unrestricted lytic capacity towards a wide range of hematological ( 21 , 25 , 29 – 33 ) and solid ( 27 , 34 – 38 ) tumor cells, without the need of prior antigen exposure or priming. CIK cell cytotoxic capacity is exerted by the engagement of natural killer group 2 member D (NKG2D) molecules, which recognize specific ligands known as UL16-binding protein family members (ULBP1–6) and MHC class I-related molecules A and B (MIC A/B) widely expressed on tumor cells ( 39 – 42 ).…”
Section: Defining Cik Cellsmentioning
confidence: 99%
“…The great peculiarity of such effector cells is the major histocompatibility complex (MHC)-unrestricted lytic capacity towards a wide range of hematological ( 21 , 25 , 29 – 33 ) and solid ( 27 , 34 – 38 ) tumor cells, without the need of prior antigen exposure or priming. CIK cell cytotoxic capacity is exerted by the engagement of natural killer group 2 member D (NKG2D) molecules, which recognize specific ligands known as UL16-binding protein family members (ULBP1–6) and MHC class I-related molecules A and B (MIC A/B) widely expressed on tumor cells ( 39 – 42 ).…”
Section: Defining Cik Cellsmentioning
confidence: 99%
“…Favorable outcomes achieved with CIK cell therapy led to increased efforts to improve the efficacy of combined approaches. There exists strong preclinical evidence on the synergistic efficacy of pro-inflammatory cytokines such as interleukins [101][102][103][104] and interferon [105] as well as cytotoxic agents [106], novel small molecule inhibitors [107][108][109], immune checkpoint inhibitors [110][111][112], monoclonal antibodies [113,114] and dendritic cell [115][116][117] or viral-based vaccines [118][119][120] combined with adoptive cell therapy. Several stromal or intracellular mechanisms implicated in synergistic activity have been identified.…”
Section: Combined İmmunotherapy Approaches: Rationale and Preclinica...mentioning
confidence: 99%
“…Favorable outcomes achieved with CIK cell therapy led to increased efforts to improve efficacy with combined approaches. There exists strong preclinical evidence on the synergistic efficacy of proinflammatory cytokines such as interleukins (101)(102)(103)(104) and interferon (105) as well as cytotoxic agents (106), novel small molecule inhibitors (107)(108)(109), immune checkpoint inhibitors (110)(111)(112), monoclonal antibodies (113,114) and dendritic cell (115)(116)(117) or viral-based vaccines (118-120) combined with adoptive cell therapy. Several stromal or intracellular mechanisms implicated in the synergistic activity have been identified.…”
Section: Combined Immunotherapy Approaches: Rationale and Preclinical...mentioning
confidence: 99%