Preclinical impairment of myocardial function in rheumatoid arthritis patients

Baktır, Ahmet Oğuz; Şarlı, Bahadır; Çebicci, Mehtap Aykaç; Sağlam, Hilal; Doğan, Yüksel; Demirbaş, Melih; Sütbeyaz, Serap Tomruk; Arınç, Hüseyin

doi:10.1007/s00059-014-4068-3

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Moreover, GLS has been shown to be able to predict a reduced cardiopulmonary exercise capacity and the onset of ventricular arrhythmias [72], increasing its prognostic relevance. Similar results have been obtained in the evaluation of LV function by using GLS in patients with β -thalassemia major [73] and rheumatoid arthritis [74].…”

Section: Systemic Diseases and Neuromuscular Disorderssupporting

confidence: 83%

Ten Years of 2D Longitudinal Strain for Early Myocardial Dysfunction Detection: A Clinical Overview

Zito

Longobardo

Citro

et al. 2018

BioMed Research International

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In recent years, the role of left ventricular ejection fraction (EF) as the gold standard parameter for the evaluation of systolic function has been questioned, and many efforts have been concentrated in the clinical validation of new noninvasive tools for the study of myocardial contractility. Improvement in the accuracy of speckle-tracking echocardiography has resulted in a large amount of research showing the ability of two-dimensional strain to overcome EF limitations in the majority of primary and secondary heart diseases. Currently, global longitudinal strain (GLS) is considered the most accurate and sensitive parameter for the assessment of early left ventricular dysfunction. This review summarizes the advantages that this measurement can provide in several clinical settings. Moreover, the important cautions that should be considered in making the choice to use GLS also are addressed. Finally, a special focus on bull's-eye polar maps for the assessment of regional changes of longitudinal function and the usefulness of these maps in the differential diagnosis of several diseases is provided.

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Section: Systemic Diseases and Neuromuscular Disorderssupporting

confidence: 83%

Ten Years of 2D Longitudinal Strain for Early Myocardial Dysfunction Detection: A Clinical Overview

Zito

Longobardo

Citro

et al. 2018

BioMed Research International

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“…Recently, velocity, displacement, and deformation imaging (strain and strain-rate) as estimated by speckle-tracking echocardiography (STE) were documented to represent valuable tools in the comprehensive and reliable assessment of myocardial systolic function [18][19][20][21]. Interestingly, impaired myocardial deformation in the presence of a normal ejection fraction was reported in RA [22][23][24]. Myocardial deformation is related to inflammation [25,26], disease activity and/or severity in RA [17,23,24].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, impaired myocardial deformation in the presence of a normal ejection fraction was reported in RA [22][23][24]. Myocardial deformation is related to inflammation [25,26], disease activity and/or severity in RA [17,23,24]. Until recently, the lack of high-sensitive imaging has limited the use of STE in small animal models.…”

Section: Introductionmentioning

confidence: 99%

Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

et al. 2020

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Background High-grade inflammation may play a pivotal role in the pathogenesis of left ventricular (LV) dysfunction. Evidence to support a role of systemic inflammation in mediating impaired LV function in experimental models of rheumatoid arthritis (RA) remains limited. The aim of the present study was to determine the effects of high-grade systemic inflammation on LV diastolic and systolic function in collagen-induced arthritis (CIA).

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“…На сегодняшний день выявление нарушений укорочения мышечных волокон с помощью техник визуализации деформации миокарда считается более чувствительным показателем доклинической кардиомиопатии, чем ДД. Рядом авторов показано снижение глобальной продольной и поперечной деформации ЛЖ и ПЖ у больных РА по сравнению со здоровыми лицами [9,10,[33][34][35][36][37][38]. Снижение деформации наблюдается у больных РА без ССЗ и ТФР по сравнению с контролем при отсутствии различий в показателях ЭХО-КГ с ТДГ, что подтверждает трудности выявления миокардиальной дисфункции [33].…”

Section: эхокардиографические особенности диагностики хронической серunclassified

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

Новикова¹,

Udachkina²,

Kirillova³

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Rheumatoid arthritis (RA) is characterized by a twofold increase in morbidity and mortality due to chronic heart failure (CHF). At the same time, the prevalence of CHF among RA patients is significantly underestimated. The aim of the review was to analyze the results of the main studies on the features of the clinical presentation of heart failure (HF) in RA patients, the role of visualization techniques and biomarkers in the diagnosis of HF and preclinical dysfunction of the myocardium. HF in patients with RA is characterized by a predominance of HF with a preserved left ventricular ejection fraction (LVEF). The use of clinical diagnostic criteria in RA patients can lead to both over- or underdiagnosis of CHF. Systolic dysfunction estimated by LVEF is rare in RA and does not reflect the real frequency of myocardial dysfunction. Echocardiography (ECHO-CG) with tissue Doppler echocardiography (TDE) and visualization of myocardial deformation, magnetic resonance imaging (MRI) of the heart in RA patients revealed a high frequency of HF with preserved ejection fraction, left ventricular remodeling and hypertrophy, pre-clinical systolic and diastolic dysfunction. Determination of natriuretic peptides is useful for verifying the diagnosis of HF and estimating the prognosis in this cohort, despite the possible decrease in the sensitivity and specificity of these indicators in RA patients. The review discusses the advantages of MRI of the heart, including quantitative T1 and T2 regimens, in the diagnosis of myocarditis, myocardial fibrosis, and myocardial perfusion disorders in RA patients. In order to verify the diagnosis of heart failure and detect pre-clinical myocardial dysfunction in RA patients, the determination of natriuretic peptides concentration should become part of the routine examination, beginning with the debut of the disease, along with the collection of a cardiological history, physical examination, ECHO-CT with TDE, and visualization of myocardial deformation. Evaluation of the quantitative characteristics of tissue according to MRI of the heart could improve the diagnosis of myocardial damage.

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Preclinical impairment of myocardial function in rheumatoid arthritis patients

Cited by 11 publications

References 18 publications

Ten Years of 2D Longitudinal Strain for Early Myocardial Dysfunction Detection: A Clinical Overview

Ten Years of 2D Longitudinal Strain for Early Myocardial Dysfunction Detection: A Clinical Overview

Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

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