2020
DOI: 10.30895/1991-2919-2020-10-3-164-176
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Preclinical in vivo Neurotoxicity Studies of Drug Candidates

Abstract: Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity. Current experimental approaches to neurotoxicity assessment are cumbersome, laborious and not adapted enough for preclinical studies in the early stages of drug development. The aim of the study was to review existing approaches to experimental assessment of neurotoxic potential of … Show more

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