Preclinical model of transcorneal alternating current stimulation in freely moving rats

Sergeeva, Elena G.; Henrich‐Noack, Petra; Gorkin, Alexander; Sabel, Bernhard A.

doi:10.3233/rnn-150513

Cited by 8 publications

(7 citation statements)

References 38 publications

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“…In addition, donepezil could by itself have a protective effect of ganglion cells in the retina [ 61 , 62 ] but the VEP recordings from the present study show that the retino-cortical function was not restored after 21 days after the crush. These results are in line with other studies using the ONC model in animals where the VEPs are deteriorated immediately after the crush and do not show any recovery for weeks [ 63 , 64 ]. Additionally, in the case of optic disease in human, which is mimicked by the rat ONC model and which leads to partial vision loss, electrophysiology and imaging studies prove that diminished visual brain function related to the optic neuritis eyes is correlated with the extent of the optic nerve damage [ 65 – 67 ].…”

Section: Discussionsupporting

confidence: 92%

Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

et al. 2017

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Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.

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Section: Discussionsupporting

confidence: 92%

Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

et al. 2017

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“…However, beneficial effects of ES have been shown in one study using transorbital ES 14 and in several animal experiments using TES (Table 1). 15e35 These studies can be categorized as follows: i) healthy animals 17e19, 23,26,31,34 ; ii) transgenic animals 22,28 ; iii) animals as a disease model for RP 21 ; iv) animals with induced ischemic insult, 27,29,33 optic nerve crush, 15,16,20,32 and transected optic nerve 24,25 ; and v) animal cells isolated from the retina. 35 …”

Section: Animal Experimentsmentioning

confidence: 99%

“…Recently, Sergeeva et al 31 successfully generated a new method for TES and flicker light stimulation in freely moving rats as well as a setup to record field potentials from the visual cortex and subcortical structures. A considerable advantage of this novel animal model, compared to what was described in previous studies, 16,21,24,30 was the possibility to stimulate nonanesthetized rats.…”

Section: Tes and Changes In Brain Activitymentioning

confidence: 99%

Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

138

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Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies. Various mechanisms are believed to underlie the effects of ES, including increased production of neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. Promising effects of ES have also been demonstrated in clinical studies; however, all current studies have a lack of randomization and/or a control group (sham). There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies. In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision. (Am J Pathol 2016 http://dx

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“…It is crucial that the beneficial effects of TCES are not limited to retinal neurons and also extend to the cortical activity. [13][14][15] Furthermore, the low-intensive whole-eye electrical stimulation in rats with hereditary retinal degeneration having a beneficial effect on visual function gives a particularly significant impact for responses of post-receptoral neurons. 16 Multiple mechanisms have been proposed underlying the beneficial effects of electrical stimulation (for review see) 5,15 including vasodilatory, neurotrophic, anti-apoptotic, antiexcitotoxic and anti-inflammatory mechanisms.…”

Section: Current Issues Of Minimally Invasive and Prosthesis Electricmentioning

confidence: 99%

“…30,34,110 Intraperitoneally injected N-Methyl-N-nitrosourea (MNU) is known to lead to the apoptotic death of photoreceptors causing remodeling of the inner retina, however, sparing RGCs up to three months after injection. [112][113][114] Besides the rhythm of discharges of the RGCs, there is observed another rhythmic electrical activity in the rd1 and rd10 mice retinas -the LFPs, which is recording with the same frequencies as for the spiking discharges (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). LFPs reflect the changes in the extracellular voltage in the RGCs caused by correlated trans-membrane currents.…”

Section: Retinal Noisementioning

confidence: 99%

Electrical stimulation of the retina: aspects arising from retinal noise

Marina¹

2018

AOVS

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Various impacts of the spontaneous neuronal noise on visual processing in the brain and the retina are extensively studying and discussing. Highly variable behavior is characteristic of healthy physiological systems, but dynamics of functional activity is simplifying in pathology and became either very ordered or characterized by entirely uncorrelated random oscillations. It has been demonstrated by several research groups that in hereditary retinal degeneration, sensory deafferentation arising from the loss of photoreceptors increases the spontaneous activity throughout the visual system and leads an aberrant rhythmic activity of retinal ganglion cells. In patients blind due to retinitis pigmentosa, retinal prosthetic devices are currently applying to obtain visual sensations induced by the electrical pulses. The right choice of the parameters of electrical stimuli is of great importance for achieving reliable responses from the RGCs and transmittance of encoded visual information to the brain. The temporal parameters of stimulation are supposed to be crucial to provide the further innovation development of such approach. We hypothesize that the periodic pathological activity in retinal degeneration not only is a factor that hampers the encoding of information and visual images of more quality. It also can aggravate the impact of deafferentation and play the negative role of in a formation of abnormal synaptic contacts during retinal remodeling contributing to the distortion of the complexity of neural circuits in the retina and the brain in retinal degenerations. We guess that the optical flicker and electrical stimulation therapy using the complex-structured (fractal) signals can be the promising approach providing both tuning the temporal sensitivity of the visual system and activation of the neuronal plasticity throughout the visual pathway. Future strategies of vision restoration apparently must be aimed to avoid the rhythmic activity in retinal circuits and to increase the quality of image representation. Here, we present the arguments that the utilizing the fractal modulation of the stimulating pulses in amplitude or frequency as well as using fractal temporal patterns in the background electrical prestimulation may be one of the prospective ways in future elaboration successful retinal prosthesis.

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Preclinical model of transcorneal alternating current stimulation in freely moving rats

Cited by 8 publications

References 38 publications

Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

Electrical Stimulation as a Means for Improving Vision

Electrical stimulation of the retina: aspects arising from retinal noise

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