Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto, Keiichiro; Hasegawa, Mana; Piriyaprasath, Kajita; Kakihara, Yoshito; Saeki, Makio

doi:10.1016/j.jdsr.2021.10.002

Cited by 8 publications

(11 citation statements)

References 207 publications

(347 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, daily treadmill running decreases formalin-evoked nocifensive behaviors, particularly in the late phase in SDSsusceptible mice. These findings indicate that the effects of treadmill running on nociception could be mediated through neural changes in the CNS, since behavioral responses in the late phase are regulated by the CNS rather than the peripheral mechanisms [51]. Consistent with our behavioral findings, daily treadmill running decreased nociceptive neural activity in the C1/C2 region in SDS-susceptible mice, identified by the reduction of c-Fos and FosB expression in both laminae I-II and III-V.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have demonstrated that psychophysical stress can increase deep craniofacial nociception. For example, chronic restrain stress [10,11,12,51] and repeated forced swim stress [7,9,40,56] increase nociceptive responses in the TMJ and masseter muscle. Although the chronic restraint stress [10][11][12] and forced swim stress [7][8][9] models contribute to determining the basis for stress-induced nociceptive responses, they include significant levels of physical stressors.…”

Section: Discussionmentioning

confidence: 99%

“…It is well documented that neural changes in the Vc and C1/C2 regions play critical roles in increasing nociception in the deep craniofacial tissues [5,51,56]. Imaging studies have revealed that patients with TMD display structural and functional changes in the brain, including the Vc region [6].…”

Section: Discussionmentioning

confidence: 99%

“…The location of the C1/C2 region was identified by landmark structures in the C1 and C2 regions using an atlas of the mouse spinal cord [51][52][53][54][55]. The mean number of c-Fos-and FosB-immunoreactive cells was calculated from the total number of immunoreactive cells in the five sections (Figure 7).…”

Section: Animal Preparations and C-fos And Fosb Immunohistochemistrymentioning

confidence: 99%

See 3 more Smart Citations

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Hasegawa

Piriyaprasath

Ôtake

et al. 2022

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

We investigated the effects of social defeat stress (SDS) and treadmill running on masseter muscle nociception, which was quantified by the orofacial formalin test and c-Fos and FosB immunoreactivities in the upper cervical spinal cord (C1/C2) region in male mice. After daily SDS or non-SDS conditioning for 10 days, SDS-conditioned mice were categorized into SDS-susceptible versus resilient mice. Several mice, including non-SDS-conditioned, SDS-susceptible, and resilient mice, were selected to assess masseter muscle nociception on Day 11. SDS conditioning for 10 days increased masseter muscle-evoked nocifensive behaviors and c-Fos and FosB expression in SDS-susceptible compared to non-SDS and resilient mice. The remaining SDS-susceptible and non-SDS mice were subjected to an additional 10 days of SDS plus treadmill running or sedentary sessions before assessing masseter muscle nociception on Day 21. Daily treadmill running sessions reduced enhanced masseter muscle nociception in SDS-susceptible mice but not in non-SDS mice. The preventive effects of daily treadmill running immediately after each SDS conditioning for 10 days on orofacial nocifensive behaviors were assessed on Day 11. Treadmill running conducted immediately after daily SDS inhibited enhanced orofacial nocifensive behaviors. These findings indicate that repeated SDS increases masseter muscle nociception, which could be prevented by daily treadmill running exercise.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Animal Preparations and C-fos And Fosb Immunohistochemistrymentioning

confidence: 99%

See 2 more Smart Citations

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Hasegawa

Piriyaprasath

Ôtake

et al. 2022

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Human experimental models of pain have been introduced and used for various purposes, including understanding pain and testing analgesics in the early stages of drug development [ 85 ]. Craniofacial and orofacial pain experimental models [ 86 , 87 ] have been used to assist in modeling aspects of migraines but remain incomplete due to their limited nature and ethical considerations. In human experimental pain models [ 88 ], various types of stimuli (e.g., chemical, mechanical, electrical) have caused short-lasting states of pain and sensitization that can be measured by various methods (e.g., quantitative sensory testing, brain imaging, biological biomarkers).…”

Section: Human Brain Organoids For Migrainementioning

confidence: 99%

Human Brain Organoids in Migraine Research: Pathogenesis and Drug Development

Gazerani

2023

IJMS

View full text Add to dashboard Cite

Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to treat disease. Organoids of the liver, kidney, intestine, lung, and brain have been developed in recent years. Human brain organoids are used for understanding pathogenesis and investigating therapeutic options for neurodevelopmental, neuropsychiatric, neurodegenerative, and neurological disorders. Theoretically, several brain disorders can be modeled with the aid of human brain organoids, and hence the potential exists for understanding migraine pathogenesis and its treatment with the aid of brain organoids. Migraine is considered a brain disorder with neurological and non-neurological abnormalities and symptoms. Both genetic and environmental factors play essential roles in migraine pathogenesis and its clinical manifestations. Several types of migraines are classified, for example, migraines with and without aura, and human brain organoids can be developed from patients with these types of migraines to study genetic factors (e.g., channelopathy in calcium channels) and environmental stressors (e.g., chemical and mechanical). In these models, drug candidates for therapeutic purposes can also be tested. Here, the potential and limitations of human brain organoids for studying migraine pathogenesis and its treatment are communicated to generate motivation and stimulate curiosity for further research. This must, however, be considered alongside the complexity of the concept of brain organoids and the neuroethical aspects of the topic. Interested researchers are invited to join the network for protocol development and testing the hypothesis presented here.

show abstract

Development of a model to investigate the effects of prolonged ischaemia on the muscles of mastication of male Sprague Dawley rats

Makar

Nazemi

Gong

et al. 2023

Archives of Oral Biology

View full text Add to dashboard Cite

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Cited by 8 publications

References 207 publications

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice

Human Brain Organoids in Migraine Research: Pathogenesis and Drug Development

Development of a model to investigate the effects of prolonged ischaemia on the muscles of mastication of male Sprague Dawley rats

Contact Info

Product

Resources

About