2023
DOI: 10.1002/lary.30762
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Preclinical Models of Laryngeal Papillomavirus Infection: A Scoping Review

Abstract: ObjectiveLaryngeal human papillomavirus (HPV) infection causes recurrent respiratory papillomatosis (RRP) and accounts for up to 25% of laryngeal cancers. Lack of satisfactory preclinical models is one reason that treatments for these diseases are limited. We sought to assess the literature describing preclinical models of laryngeal papillomavirus infection.Data SourcesPubMed, Web of Science, and Scopus were searched from the inception of database through October 2022.Review MethodsStudies searched were screen… Show more

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“…Preclinical models are needed to further understand RRP disease pathogenesis and to develop medical treatments. In vitro models of human RRP typically retain HPV DNA only in the short term 3 . Animal models of laryngeal papillomavirus infection can retain viral DNA and disease phenotypes for months to years, 3 making these models an attractive option for modeling human RRP.…”
Section: Introductionmentioning
confidence: 99%
“…Preclinical models are needed to further understand RRP disease pathogenesis and to develop medical treatments. In vitro models of human RRP typically retain HPV DNA only in the short term 3 . Animal models of laryngeal papillomavirus infection can retain viral DNA and disease phenotypes for months to years, 3 making these models an attractive option for modeling human RRP.…”
Section: Introductionmentioning
confidence: 99%