Preclinical models of sexual desire: conceptual and behavioral analyses

Ågmo, Anders; Turi, Anne Lene; Ellingsen, Ellinor; Kaspersen, Helge

doi:10.1016/j.pbb.2004.04.013

Cited by 132 publications

(84 citation statements)

References 157 publications

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“…Both steroids were purchased from Sigma (St. Louis, Mo., USA), and injected subcutaneously in 1 ml/kg and 0.2 ml/rat of peanut oil, respectively. These doses of the ovarian hormones have previously been reported to produce a lordosis quotient (LQ) close to 100 and a sexual incentive motivation of the same magnitude as that observed at proestrus/estrus in intact, cycling rats [10,17]. …”

Section: Methodsmentioning

confidence: 99%

“…This testhas been described in detail elsewhere [10]. Briefly, an oval open field is surrounded by a 45-cm-high wall in which there are two diagonally opposed openings (25 × 25 cm) at floor level.…”

Section: Methodsmentioning

confidence: 99%

“…In fact, lordosis is a tactile reflex [9] and proceptive behaviors are strongly stimulated by tactile stimuli provided by the male [reviewed in [10,11]]. Consequently, few or none of the copulatory behaviors are displayed at a distance from the male.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen-Induced Sexual Incentive Motivation, Proceptivity and Receptivity Depend on a Functional Estrogen Receptor α in the Ventromedial Nucleus of the Hypothalamus but Not in the Amygdala

et al. 2009

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The display of copulatory behaviors usually requires the presence of a mate and is, therefore, preceded by a search for and approach to a potential partner. The intensity of approach behaviors is determined by a process labeled sexual incentive motivation. Although it is known that female sexual motivation depends on estrogens, their site of action within the brain is unknown. In the present experiment, we obtained data relevant to this issue. An shRNA encoded within an adeno-associated viral (AAV) vector directed against the estrogen receptor α (ERα) gene (or containing a nonsense base sequence as a control treatment) was injected bilaterally into the ventromedial nucleus of the hypothalamus (VMN) or the posterodorsal amygdala (MePDA) of female rats. After an 80% reduction of the number of ERα in the VMN, sexual incentive motivation was absent after treatment with estradiol and progesterone. Proceptivity and receptivity were also much reduced, while the number of rejections was enhanced. Suppression of the ERα in the MePDA lacked these effects. Likewise, the inactive control AAV vector failed to modify any behavior. Thus, the ERα in the VMN, but not in the MePDA, is important for proceptivity and receptivity as well as for sexual incentive motivation. These results show that ERα in the VMN is crucial for the entire sequence of behavioral events from the processes leading to the establishment of sexual contact until the accomplishment of copulatory behaviors.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Estrogen-Induced Sexual Incentive Motivation, Proceptivity and Receptivity Depend on a Functional Estrogen Receptor α in the Ventromedial Nucleus of the Hypothalamus but Not in the Amygdala

et al. 2009

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“…Further, the effect of MKAC9 on sexual behavior in rats was investigated employing pharmacological model of mating behavior (i.e., copulatory test). The rodent model was selected for this study since the basic neural and behavioral mechanisms controlling sexual desire and motivation are similar in rodents and in humans [23]. Also, it is a valid reliable model of rodent in sexual motivation which was proved to be of great utility for studying the behavioral and neurobiological basis of sexual motivation as well as sexual dysfunction [23].…”

Section: Discussionmentioning

confidence: 99%

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Vyawahare¹,

Hadambar²,

Chothe³

et al. 2011

J Chem Biol

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Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.

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“…Therefore, displays of paracopulatory behavior seldom occur when a male is at a large distance from the female. Paracopulatory behavior is intensely activated by tactile stimulation provided by the male (Ågmo, 2007;Ågmo, Turi, Ellingsen, & Kaspersen, 2004 Bergheim, Chu, & Ågmo, 2015). Chu and Ågmo (2016) int.j.psychol.res.…”

mentioning

confidence: 99%

Studies of Sociosexual Interactions in Rats in an Externally Valid Procedure: Are They Relevant for Understanding Human Sexual Behavior?

Chu¹,

Ågmo²

2016

Int. j. psychol. res.

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When a prolonged observation of groups of rats in a seminatural environment is used as testing procedure, different behavioral patterns are shown compared with what observed in a pair housed in a small cage. Males and females copulate simultaneously, they show a promiscuously and random copulatory pattern. Females remain completely receptive from the first lordosis displayed in the period of behavioral estrus until the last. There is no reduction in paracopulatory behaviors and no increase in rejections towards the end of estrus. Female paracopulatory behavior and receptivity change in a most abrupt way at both initiation and termination of behavioral estrus. It appears that, in the seminatural environment, males copulate in bouts, and males do not pursue the females unless they are fully receptive. Non-sexual, social behavior including affiliative and nonaffiliative interaction among rats is rather unrelated to sexual activities in both sex. Cuando una observación prolongada de grupos de ratas en ambientes seminaturales es usada como procedimiento de evaluación, diferentes patrones conductuales se muestran en comparación con lo que se observa con una pareja en una jaula pequeña. Machos y hembras copulan simultáneamente, muestran promiscuidad y un patrón aleatorio de copulación. Las hembras permanecen completamente receptivas desde su primera lordosis desplegada en el periodo de comportamiento de celo hasta el último. No hay una reducción de comportamientos para-copulatorios y no hay incremento en el rechazo hacia el final del celo. Las conductas para-copulatorias en hembras y la receptividad cambian de la manera más abrupta tanto al iniciarse como al terminarse la conducta de celo. Al parecer, en un ambiente seminatural, los machos copulan en peleas y no persiguen a las hembras a menos que ellas estén totalmente receptivas. Conductas sociales no sexuales, incluidas las interacciones afiliativas y no afiliativas entre ratas, no están relacionadas con actividades sexuales en ambos sexos.

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Preclinical models of sexual desire: conceptual and behavioral analyses

Cited by 132 publications

References 157 publications

Estrogen-Induced Sexual Incentive Motivation, Proceptivity and Receptivity Depend on a Functional Estrogen Receptor α in the Ventromedial Nucleus of the Hypothalamus but Not in the Amygdala

Estrogen-Induced Sexual Incentive Motivation, Proceptivity and Receptivity Depend on a Functional Estrogen Receptor α in the Ventromedial Nucleus of the Hypothalamus but Not in the Amygdala

Effect of novel synthetic evodiamine analogue on sexual behavior in male rats

Studies of Sociosexual Interactions in Rats in an Externally Valid Procedure: Are They Relevant for Understanding Human Sexual Behavior?

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