Preclinical Models of Tumor Growth and Response

McConville, Patrick; Elliott, William L.; Kreger, Alicia R.; Lister, Richard J.; Moody, Jonathan B.; Trachet, Erin; Urban, F. A.; Leopold, Wilbur R.

doi:10.1007/978-1-59745-341-7_2

Cited by 4 publications

(4 citation statements)

References 93 publications

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“…In situ models, including chemically induced, transgenic and spontaneous models, are considered less adapted for the evaluation of experimental therapies because of their inherent variability and the relatively long-time delay required for tumour growth and response to treatment [2]. While ectopic models are frequently employed owing to the ease of their implantation, orthotopic models are considered to better reflect the tumour physiological environment.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

Séguin

Doan

Ossa

et al. 2013

International Journal of Molecular Imaging

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Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (<5 min) compared to MRI. Conclusion. MRI and US afforded excellent noninvasive imaging techniques to accurately follow tumour growth of ectopic and orthotopic CT26 tumours. These two techniques can be appropriately used for tumour treatment followup, with a preference for US imaging, due to its short acquisition time and simplicity of use.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

Séguin

Doan

Ossa

et al. 2013

International Journal of Molecular Imaging

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“…56 Hence the argument that searching for abstract and generalist structures takes us away from`the richness of reality' 57 and is, fundamentally, an example of subjectivism'. Travers argued that McConville et al dismissed 58 this division's implications too readily. 59 The result is that it is`remarkably easy' to criticize their findings.…”

Section: Methods Of Analysismentioning

confidence: 99%

The Way in Which Fee Reductions Influence Legal Aid Criminal Defence Lawyer Work: Insights from a Qualitative Study

Thornton

2019

Journal of Law and Society

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This article examines how fee reductions influence criminal defence lawyers’ work. Data from 29 qualitative interviews with English defence solicitors and barristers are analysed in order to understand the way in which cuts to fees paid by government for criminal legal aid work can operate to influence criminal defence lawyers’ working practices. I use game theory and Bourdieu's concepts of habitus and field to build a theoretical construct illustrating the invidious position current financial conditions place criminal legal aid lawyers in. I argue that these conditions reward and encourage perceived poor practices and values to thrive at the expense of other concerns – such as the conviction of the guilty, acquittal of the innocent, fair treatment of both victims and defendants, and value for the taxpayer. Ultimately, I argue that criminal legal aid lawyers are set up to fail by the current financial conditions within which they must work.

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“…A growing interest in the fluorescence imaging technique has been stimulated in recent years by the emergence of high-power compact light sources operating at various wavelengths, of high-sensitivity optical detectors and novel bright contrast agents, such as fluorescent proteins (FPs), which enable noninvasive study of cellular processes [2][3][4]. Today, whole-body fluorescence imaging has become an important tool in preclinical studies of small animals [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence diffuse tomography technique with autofluorescence removal based on dispersion of biotissue optical properties

Kleshnin¹,

Turchin²

2013

Laser Phys. Lett.

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The dispersion of biotissue optical properties results in distortion of the spectrum of radiation during propagation through biotissues. This phenomenon can be used for solving the inverse problem in fluorescence diffuse tomography. We have developed the spectrally resolved fluorescence diffuse tomography (SFDT) technique, which allows reconstruction of the spatial distribution of the fluorophore in biotissue even in the presence of unknown autofluorescence. The experimental setup combining epi-illumination and trans-illumination imaging geometries with spectral resolution has been created. Experimental studies on tissue phantoms and small animals in vivo with the proposed SFDT technique have been conducted. The obtained results have shown high accuracy of the inverse problem solution for spatial distribution of fluorophore concentration.

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Preclinical Models of Tumor Growth and Response

Cited by 4 publications

References 93 publications

Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

The Way in Which Fee Reductions Influence Legal Aid Criminal Defence Lawyer Work: Insights from a Qualitative Study

Fluorescence diffuse tomography technique with autofluorescence removal based on dispersion of biotissue optical properties

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