Preclinical orthotopic xenograft model of renal pelvis cancer in which cancer growth could be traced by an in vivo imaging system

Editorial Comment to Effectiveness of the combination of vascular targeted photodynamic therapy and anti‐cytotoxic T‐lymphocyte‐associated antigen 4 in a preclinical mouse model of urothelial carcinoma

“…In this study, the authors used an ectopic model of subcutaneous cancer cell engraftment; however, orthotopic models of urinary bladder or renal pelvis might be preferable, as they better reflect the natural behavior of UC cells. This could be accomplished by transurethral administration of UC cancer cells, as we reported previously . As the results of this strategy showed that a combination of immunomodulatory agents and ICIs can yield successful results, various immunomodulatory agents have been investigated.…”

Editorial Comment from Dr Miyake to Preclinical orthotopic xenograft model of renal pelvis cancer in which cancer growth could be traced by an in vivo imaging system

“…In this issue, Shimizu et al . reported the novel orthotopic xenograft model of renal pelvis cancer using an in vivo imaging system . This experimental approach can provide technical improvement in that tumor growth could be traced non‐invasively, visually and objectively by calculating cancer cells expressing luciferase signal quantified using the region of interest tool without euthanizing animals.…”