2022
DOI: 10.3390/nano12244471
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Preclinical PET and MR Evaluation of 89Zr- and 68Ga-Labeled Nanodiamonds in Mice over Different Time Scales

Abstract: Nanodiamonds (NDs) have high potential as a drug carrier and in combination with nitrogen vacancies (NV centers) for highly sensitive MR-imaging after hyperpolarization. However, little remains known about their physiological properties in vivo. PET imaging allows further evaluation due to its quantitative properties and high sensitivity. Thus, we aimed to create a preclinical platform for PET and MR evaluation of surface-modified NDs by radiolabeling with both short- and long-lived radiotracers. Serum albumin… Show more

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Cited by 10 publications
(2 citation statements)
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“…Additionally, NDs inherit intrinsic para- and diamagnetic properties, ultimately resulting in longitudinal relaxation time ( T 1 )-enhancement when used as a contrast agent in magnetic resonance imaging (MRI) [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Additionally, NDs inherit intrinsic para- and diamagnetic properties, ultimately resulting in longitudinal relaxation time ( T 1 )-enhancement when used as a contrast agent in magnetic resonance imaging (MRI) [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…In previous studies, we explored the potential of NDs for positron-emission tomo-graphy (PET) imaging [ 10 , 17 ]. In these studies, we coated NDs with cationized human serum albumin (cHSA) and polyethylene glycol (PEG) and added a chelator (DFO) for radiolabeling.…”
Section: Introductionmentioning
confidence: 99%