Preclinical radiation internal dosimetry in the development of new radiopharmaceuticals using GATE Monte Carlo simulation

Voxel-based dose calculation of radionuclide imaging and therapy for preclinical studies using GEANT4 Monte Carlo simulation

“…The reduction of time mainly comes from difference of source sampling methods. In traditional methods, the rejection method is often used for source sample which limits the efficiency to some extends (9,10) . On the other hand, the uncertainty of dose in the organs with lower activity could be reduced by the uniformed sampling method comparing traditional methods, e.g.…”

“…Establishing the database of S-values for various radioactive nuclides with a variety of voxel dimensions has a huge workload, which is yet not available. In addition, another method that can be used for internal radiation dose assessment is Monte Carlo(MC), which is currently considered to be a most accurate method in the field of dose assessment because it simulates the detail transportation process of particles in objects (9,10) . Based on the animal phantoms, specific absorbed fractions, S-values and absorbed doses of several radionuclides have been calculated by the use of MC software, such as EGS, MCNP, GAMOS, GATE, etc.…”

ESTIMASI DOSIS 99mTc-PERTEHNETAT DARI GENERATOR 99Mo / 99mTc NON-FISI PADA ANAK-ANAK USIA 1-15 TAHUN UNTUK PROSEDUR DIAGNOSTIK

“…Pengembangan suatu radiofarmaka baru diperlukan pengujian prakilinis berupa uji biodistribusi. Sebelum suatu radiofarmaka diujikan pada manusia, terlebih dahulu harus menjalani studi aplikasi biodistribusi dan dosimetri radiasi pada hewan untuk menentukan keamanan dan efektivitasnya (klinis) [16]. Uji biodistribusi adalah metode yang berguna untuk melihat penyebaran radiofarmaka ke organ target dan organ lainnya, serta sisa penyerapan radiofarmaka di dalam organ [17,18].…”