Preclinical Studies for Development of Biomedical Products

Nematizadeh, Mehran; Payab, Moloud; Gholami, Mahdi; Arjmand, Babak; Larijani, Bagher; Tayanloo-Beik, Akram

doi:10.1007/978-3-030-35626-2_5

Cited by 2 publications

(2 citation statements)

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“…However, the use of animal models in preclinical studies is still controversial. Because the use of animals in scientific studies requires the observance of strict ethical principles (72,(182)(183)(184). Thus, in recent years, studies in the field of neurological disorders have led to the use of new technologies such as organ-on-a-chip.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the guidelines of preclinical studies establish some strict policies to ensure the observation of the highest standards and ethical principles of working with animals. For instance, a developing well-designed study and applying methods appropriate to the research goals, selecting animal models appropriate to the purpose of the study, employing a sufficient number of animals, taking any necessary measures to maintain animal welfare and safety, and trying to use alternatives to animal models, are among the most critical ethics that should be considered in animal studies ( 72 ). Regarding the mentioned ethical principles and international and regional guidelines, over the last decades, Zebrafish has attracted attention as a prominent animal model in various in vivo experiments ( 73 ), such as ASD studies due to its prominent neurological characteristics ( 74 ).…”

Section: Zebrafish As An Appropriate Animal Model For Autism Spectrum...mentioning

confidence: 99%

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Zebrafish Modeling of Autism Spectrum Disorders, Current Status and Future Prospective

et al. 2022

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Autism spectrum disorder (ASD) refers to a complicated range of childhood neurodevelopmental disorders which can occur via genetic or non-genetic factors. Clinically, ASD is associated with problems in relationships, social interactions, and behaviors that pose many challenges for children with ASD and their families. Due to the complexity, heterogeneity, and association of symptoms with some neuropsychiatric disorders such as ADHD, anxiety, and sleep disorders, clinical trials have not yielded reliable results and there still remain challenges in drug discovery and development pipeline for ASD patients. One of the main steps in promoting lead compounds to the suitable drug for commercialization is preclinical animal testing, in which the efficacy and toxicity of candidate drugs are examined in vivo. In recent years, zebrafish have been able to attract the attention of many researchers in the field of neurological disorders such as ASD due to their outstanding features. The presence of orthologous genes for ASD modeling, the anatomical similarities of parts of the brain, and similar neurotransmitter systems between zebrafish and humans are some of the main reasons why scientists draw attention to zebrafish as a prominent animal model in preclinical studies to discover highly effective treatment approaches for the ASD through genetic and non-genetic modeling methods.

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Section: Discussionmentioning

confidence: 99%