Preclinical Toxicological Profile of Hydroalcholic Leaf Extract of Ipomoea aquatica Forsk an Indian Medicinal Plant

Sivaraman, D.; Panneersel, P.; Muralidhar, P.; Prabhu, T. Purushoth

doi:10.5567/pharmacologia.2013.107.116

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2023

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“…Acute oral toxicity test exhibited that pseudo-LD50 was more than 9375 mg/kg, and no toxic effect was detected in both sexes of Wistar rats 6 . In Sivaraman et al study 7 , no mortality and clinical signs changed at the maximum 2000 mg/kg dose. Administration of ethanolic extract of I. reptans for 14 days on female mice showed that AST and ALT values increased significantly at doses of 759 and 1200 mg/kg.…”

Section: Introductionmentioning

confidence: 85%

Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats

et al. 2023

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Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract had an LD50 cut-off value of 5000 mg/kg.

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Section: Introductionmentioning

confidence: 85%